中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2013年
6期
390-393
,共4页
孙丽伟%李杰%康尔恂%韩春玉%闫丽萍%金外淑%夏秀娟
孫麗偉%李傑%康爾恂%韓春玉%閆麗萍%金外淑%夏秀娟
손려위%리걸%강이순%한춘옥%염려평%금외숙%하수연
荨麻疹%自身抗体%免疫球蛋白E%皮肤试验
蕁痳疹%自身抗體%免疫毬蛋白E%皮膚試驗
담마진%자신항체%면역구단백E%피부시험
Urticaria%Autoantibodies%Immunoglobulin E%Skin tests
目的 探讨抗高亲和力IgE受体(FcεRI)抗体、抗IgE抗体、抗幽门螺杆菌(HP)抗体和抗甲状腺球蛋白抗体(TGAb)与慢性特发性荨麻疹(CIU)发病的关系.方法 设(CIU)组、急性荨麻疹(AU)组和健康对照组,每组100例受试者.每例受试者均进行自体血清皮肤试验,荧光酶联免疫吸附法检测过敏原,血清总IgE、抗FcεRI抗体、抗IgE抗体、抗HP抗体、TGAb水平及阳性率,将CIU组与AU组和健康对照组比较.结果 CIU组自体血清皮肤试验阳性率为53％,AU组为12％,健康对照组未发现阳性者.CIU组和健康对照组过敏原检测均为阴性,而AU组能检测到食物或吸人物过敏原,阳性率为86％.CIU组抗FcεRI抗体和抗IgE抗体水平均高于AU组和健康对照组(P＜ 0.05); CIU患者IgE水平低于健康对照组(T=190.00,P＜0.05),而AU组IgE水平高于健康对照组(T=226.00,P＜0.05)；自体血清皮肤试验阳性CIU患者抗FcεRI抗体水平较阴性患者高(T=101.73,P＜ 0.05),抗IgE抗体在自体血清皮肤试验阳性和阴性CIU患者间,差异无统计学意义(T=312.04,P＞0.05)；CIU组、AU组、和健康对照组抗HP抗体阳性率分别为29％、19％和23％,TGAb阳性率分别为18％、15％和11％,抗HP抗体和TGAb阳性率在三组间比较,差异均无统计学意义(P＞0.05)；抗HP抗体阳性的CIU患者中,抗FcεRI抗体阳性率较AU患者和健康人高(P＜0.01)；抗IgE抗体阳性率与AU患者和健康人差异无统计学意义(P＞0.05).TGAb阳性的CIU患者中,抗FcεRI抗体阳性率较AU患者和健康人高(P＜0.01),抗IgE抗体阳性率与AU患者和健康人比较,差异无统计学意义(P＞0.05).结论 CIU存在抗FcεRI和抗IgE自身抗体,可能在自身免疫性荨麻疹发病中起一定作用.
目的 探討抗高親和力IgE受體(FcεRI)抗體、抗IgE抗體、抗幽門螺桿菌(HP)抗體和抗甲狀腺毬蛋白抗體(TGAb)與慢性特髮性蕁痳疹(CIU)髮病的關繫.方法 設(CIU)組、急性蕁痳疹(AU)組和健康對照組,每組100例受試者.每例受試者均進行自體血清皮膚試驗,熒光酶聯免疫吸附法檢測過敏原,血清總IgE、抗FcεRI抗體、抗IgE抗體、抗HP抗體、TGAb水平及暘性率,將CIU組與AU組和健康對照組比較.結果 CIU組自體血清皮膚試驗暘性率為53％,AU組為12％,健康對照組未髮現暘性者.CIU組和健康對照組過敏原檢測均為陰性,而AU組能檢測到食物或吸人物過敏原,暘性率為86％.CIU組抗FcεRI抗體和抗IgE抗體水平均高于AU組和健康對照組(P＜ 0.05); CIU患者IgE水平低于健康對照組(T=190.00,P＜0.05),而AU組IgE水平高于健康對照組(T=226.00,P＜0.05)；自體血清皮膚試驗暘性CIU患者抗FcεRI抗體水平較陰性患者高(T=101.73,P＜ 0.05),抗IgE抗體在自體血清皮膚試驗暘性和陰性CIU患者間,差異無統計學意義(T=312.04,P＞0.05)；CIU組、AU組、和健康對照組抗HP抗體暘性率分彆為29％、19％和23％,TGAb暘性率分彆為18％、15％和11％,抗HP抗體和TGAb暘性率在三組間比較,差異均無統計學意義(P＞0.05)；抗HP抗體暘性的CIU患者中,抗FcεRI抗體暘性率較AU患者和健康人高(P＜0.01)；抗IgE抗體暘性率與AU患者和健康人差異無統計學意義(P＞0.05).TGAb暘性的CIU患者中,抗FcεRI抗體暘性率較AU患者和健康人高(P＜0.01),抗IgE抗體暘性率與AU患者和健康人比較,差異無統計學意義(P＞0.05).結論 CIU存在抗FcεRI和抗IgE自身抗體,可能在自身免疫性蕁痳疹髮病中起一定作用.
목적 탐토항고친화력IgE수체(FcεRI)항체、항IgE항체、항유문라간균(HP)항체화항갑상선구단백항체(TGAb)여만성특발성담마진(CIU)발병적관계.방법 설(CIU)조、급성담마진(AU)조화건강대조조,매조100례수시자.매례수시자균진행자체혈청피부시험,형광매련면역흡부법검측과민원,혈청총IgE、항FcεRI항체、항IgE항체、항HP항체、TGAb수평급양성솔,장CIU조여AU조화건강대조조비교.결과 CIU조자체혈청피부시험양성솔위53％,AU조위12％,건강대조조미발현양성자.CIU조화건강대조조과민원검측균위음성,이AU조능검측도식물혹흡인물과민원,양성솔위86％.CIU조항FcεRI항체화항IgE항체수평균고우AU조화건강대조조(P＜ 0.05); CIU환자IgE수평저우건강대조조(T=190.00,P＜0.05),이AU조IgE수평고우건강대조조(T=226.00,P＜0.05)；자체혈청피부시험양성CIU환자항FcεRI항체수평교음성환자고(T=101.73,P＜ 0.05),항IgE항체재자체혈청피부시험양성화음성CIU환자간,차이무통계학의의(T=312.04,P＞0.05)；CIU조、AU조、화건강대조조항HP항체양성솔분별위29％、19％화23％,TGAb양성솔분별위18％、15％화11％,항HP항체화TGAb양성솔재삼조간비교,차이균무통계학의의(P＞0.05)；항HP항체양성적CIU환자중,항FcεRI항체양성솔교AU환자화건강인고(P＜0.01)；항IgE항체양성솔여AU환자화건강인차이무통계학의의(P＞0.05).TGAb양성적CIU환자중,항FcεRI항체양성솔교AU환자화건강인고(P＜0.01),항IgE항체양성솔여AU환자화건강인비교,차이무통계학의의(P＞0.05).결론 CIU존재항FcεRI화항IgE자신항체,가능재자신면역성담마진발병중기일정작용.
Objective To estimate the correlations between chronic idiopathic urticaria (CIU) development and interrelated autoantibodies,including anti-high affinity immunoglobulin E receptor (anti-FcεRI) antibody,anti-immunoglobulin E (anti-IgE) antibody,anti-Helicobacter pylori (HP) antibody and antithyroglobulin antibody (TGAb).Methods This study included 100 patients with CIU,100 patients with acute urticaria (AU) and 100 healthy controls.Autologous serum skin test (ASST) was performed and allergens were detected by fluorescence-based enzyme linked immunosorbent assay (ELISA) in each subject.Serum levels of total IgE,anti-FcεRI antibody,anti-IgE antibody,anti-HP antibody and TGAb were measured.Chi-square test,analysis of variance,and Wilcoxon rank sum test were conducted for statistical analysis.Results The positivity rate of ASST was 53％,12％ and 0 respectively in patients with CIU,patients with AU and healthy controls,respectively.Food or inhalant allergens were detected in 86％ of the patients with AU,but not detected in any of the patients with CIU or healthy controls.Patients with CIU showed significantly higher levels of anti-FcεRI antibody and anti-IgE antibody compared with patients with AU and healthy controls (all P ＜ 0.05).The serum IgE level in healthy controls was statistically lower than that in patients with AU (T =226.00,P ＜ 0.05),but higher than that in patients with CIU (T =190.00,P ＜ 0.05).ASST-positive patients with CIU had a higher level of serum anti-FcεRI antibody (T =101.73,P ＜ 0.05),but a similar level of serum anti-IgE antibody compared with ASST-negative patients with CIU (T =312.04,P ＞ 0.05).No significant differences were observed in the positivity rate of anti-HP antibody (29％,19％ and 23％,P ＞ 0.05) or TGAb (18％,15％ and 11％,P ＞ 0.05) between the patients with CIU,patients with AU and healthy controls.Both anti-HP antibody-positive patients and TGAb-positive patients with CIU showed a significantly higher positivity rate of anti-FcεRI antibody (all P ＜ 0.01),but a similar positivity rate of anti-IgE antibody compared with the patients with AU and healthy controls (all P ＞ 0.05).Conclusions Anti-FcεRI antibody and anti-IgE antibody are present in patients with CIU,and may play a certain role in the pathogenesis of CIU.
