CAJ | 학술논문

目的探讨上海两个社区特应性皮炎(AD)患儿及健康对照儿童皮肤屏障功能及AD皮损严重程度与皮肤屏障功能的相关性.方法 3～12岁AD患儿169例和健康对照儿童142例来自上海长宁新泾社区和嘉定菊园社区,检测前臂伸侧、屈侧及脸颊、胫前4个部位非皮损区的角质层含水量和经皮失水量(TEWL).并用欧洲AD评分标准(SCORAD)对AD患儿临床严重程度进行评分.结果 AD患儿前臂伸侧、屈侧及脸颊、胫前四个部位的TEWL值均高于健康对照儿童(P＜0.05),角质层含水量在前臂伸侧和胫前均显著低于健康对照儿童(P＜0.05).AD患儿SCORAD与TEWL均值呈正相关,与角质层含水量均值呈负相关.结论皮肤屏障功能可以作为评价AD临床严重程度的指标之一.
목적 탐토상해량개사구특응성피염(AD)환인급건강대조인동피부병장공능급AD피손엄중정도여피부병장공능적상관성.방법 3～12세AD환인169례화건강대조인동142례래자상해장저신경사구화가정국완사구,검측전비신측、굴측급검협、경전4개부위비피손구적각질층함수량화경피실수량(TEWL).병용구주AD평분표준(SCORAD)대AD환인림상엄중정도진행평분.결과 AD환인전비신측、굴측급검협、경전사개부위적TEWL치균고우건강대조인동(P＜0.05),각질층함수량재전비신측화경전균현저저우건강대조인동(P＜0.05).AD환인SCORAD여TEWL균치정정상관,여각질층함수량균치정부상관.결론 피부병장공능가이작위평개AD림상엄중정도적지표지일.
Objective To evaluate skin barrier function in children with atopic dermatitis (AD) as well as healthy children from two communities in Shanghai and to assess the relationship between skin barrier function and AD severity.Methods Totally,169 children with AD and 142 healthy children aged 3-12 years were recruited from two communities (Changning Xining community and Jiading Juyuan community) in Shanghai,China.Transepidermal water loss (TEWL) and stratum corneum hydration were measured in normal appearing nonlesional skin at four body sites (dorsal and volar forearm,cheek and anterior shin) of the patients,as well as in normal skin at the same sites of the controls.AD severity was evaluated by using the severity scoring of atopic dermatitis (SCORAD) index.Results Compared with the healthy children,the patients with AD showed higher TEWL value at all of the four body sites (all P ＜ 0.05),but lower water content in stratum corneum at dorsal forearm and anterior shin (both P ＜ 0.05).In patients with AD,the SCORAD index was positively correlated with mean TEWL value,but negatively correlated with the mean water content in stratum corneum.Conclusion Skin barrier function may serve as an index for evaluating the severity of AD.