CAJ | 학술논문

目的探讨寻常性银屑病的自然病程变化.方法在经过长期随访的1136例中,选择初次发病后3个月内就诊的患者作为对象,将就诊后长达20年以上的病情变化情况进行整理、归类,并将每例的发病年龄、就诊时皮疹的形态、分布范围,是否有家族史,是否使用抗癌药、或使用维生素、中药等信息逐项进行登记,然后用SPSS13.0统计学软件与病情演变类型之间进行相关性分析.结果寻常性银屑病的病程演变有6种类型,即即愈型、缓愈型、间歇发作型、频发轻型、频发中型、频发重型.初发病例经长期随访,约有30％的患者处于长期痊愈状态(即愈型+缓愈型),频发重型不足10％.经与病程演变类型相应的随访时病情严重程度(轻、中、重)与影响因素相关的统计学分析显示,发病年龄和家族史有相关性,使用抗癌药治疗有显著的负相关.结论长期随访的寻常性银屑病患者的资料能反映病程演变过程(即自然病程)的情况,对判断银屑病患者的预后、预防复发、选择治疗方法有一定的指导意义.
목적 탐토심상성은설병적자연병정변화.방법 재경과장기수방적1136례중,선택초차발병후3개월내취진적환자작위대상,장취진후장체20년이상적병정변화정황진행정리、귀류,병장매례적발병년령、취진시피진적형태、분포범위,시부유가족사,시부사용항암약、혹사용유생소、중약등신식축항진행등기,연후용SPSS13.0통계학연건여병정연변류형지간진행상관성분석.결과 심상성은설병적병정연변유6충류형,즉즉유형、완유형、간헐발작형、빈발경형、빈발중형、빈발중형.초발병례경장기수방,약유30％적환자처우장기전유상태(즉유형+완유형),빈발중형불족10％.경여병정연변류형상응적수방시병정엄중정도(경、중、중)여영향인소상관적통계학분석현시,발병년령화가족사유상관성,사용항암약치료유현저적부상관.결론 장기수방적심상성은설병환자적자료능반영병정연변과정(즉자연병정)적정황,대판단은설병환자적예후、예방복발、선택치료방법유일정적지도의의.
Objective To characterize the natural history of psoriasis vulgaris.Methods A retrospective study was carried out.Totally,245 patients admitted to hospitals within three months after the first episode of psoriasis vulgaris were selected from 1136 patients with psoriasis vulgaris who had been followed up for more than 20 years.Changes in disease severity during the long-term follow-up were traced,and information on the shape and distribution of skin lesions,family history,use of anticancer drugs,vitamins and traditional Chinese medicines was collected and analyzed.SPSS13.0 software package was utilized to assess factors associated with the evolution of psoriasis vulgaris.Results The natural course of psoriasis vulgaris could be classified into six types:immediate healing,slow healing,intermittent relapse,frequent mild relapse,frequent moderate relapse,and frequent severe relapse.The immediate healing type and slow healing type amounted to 30％ of these patients,and the frequent severe relapse type to less than 10％.Statistical analysis revealed that the clinical severity of psoriasis was associated with the age of onset and family history,and was negatively correlated with the use of anticancer drugs.Conclusions The long-term follow-up study reveals the natural course of psoriasis vulgaris,which may be helpful in guiding the prediction of prognosis,prevention of recurrence and selection of treatment.