中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2013年
10期
723-725
,共3页
曲才杰%史同新%毕健平%李永喜%魏红军%李春霞
麯纔傑%史同新%畢健平%李永喜%魏紅軍%李春霞
곡재걸%사동신%필건평%리영희%위홍군%리춘하
肿瘤,基底细胞%凋亡抑制蛋白质类%凋亡调节蛋白质类
腫瘤,基底細胞%凋亡抑製蛋白質類%凋亡調節蛋白質類
종류,기저세포%조망억제단백질류%조망조절단백질류
Neoplasms,basal cell%Inhibitor of apoptosis proteins%Apoptosis regulatory proteins
目的 探讨凋亡抑制蛋白Livin和促凋亡因子Smac在基底细胞癌中的表达.方法 用SP法检测80例基底细胞癌组织中Livin和Smac的表达,分析二者表达的相关性.结果 Livin在基底细胞癌组织中的阳性表达率为77.50％,在正常对照组为3.33％,二者比较,差异有统计学意义(x2=49.04,P＜ 0.001).Livin在结节溃疡型和色素型基底细胞癌中的阳性表达率分别为75.41％和80.00％,二者比较,差异无统计学意义(x2=0.001,P＞0.05).Livin在结节囊肿型和色素型基底细胞癌中的阳性表达率分别为73.58％和80.00％,二者比较,差异无统计学意义(x2=0.03,P＞0.05).Smac在基底细胞癌组织中的阳性表达率为46.25％,在正常对照组为100％,二者比较,差异有统计学意义(x2=26.47,P＜0.001).Smac在结节溃疡型和色素型基底细胞癌中的阳性表达率分别为47.54％和40.00％,二者比较,差异无统计学意义(x2=0.28,P＞0.05).Smac在结节囊肿型和色素型基底细胞癌中的阳性表达率分别为45.28％和40.00％,二者比较,差异无统计学意义(x2=0.13,P＞ 0.05).Livin和Smac在基底细胞癌中的表达呈负相关(r=-0.432,P＜ 0.01).结论 Livin的过表达和Smac的低表达可能在基底细胞癌的发生、发展中起一定作用.
目的 探討凋亡抑製蛋白Livin和促凋亡因子Smac在基底細胞癌中的錶達.方法 用SP法檢測80例基底細胞癌組織中Livin和Smac的錶達,分析二者錶達的相關性.結果 Livin在基底細胞癌組織中的暘性錶達率為77.50％,在正常對照組為3.33％,二者比較,差異有統計學意義(x2=49.04,P＜ 0.001).Livin在結節潰瘍型和色素型基底細胞癌中的暘性錶達率分彆為75.41％和80.00％,二者比較,差異無統計學意義(x2=0.001,P＞0.05).Livin在結節囊腫型和色素型基底細胞癌中的暘性錶達率分彆為73.58％和80.00％,二者比較,差異無統計學意義(x2=0.03,P＞0.05).Smac在基底細胞癌組織中的暘性錶達率為46.25％,在正常對照組為100％,二者比較,差異有統計學意義(x2=26.47,P＜0.001).Smac在結節潰瘍型和色素型基底細胞癌中的暘性錶達率分彆為47.54％和40.00％,二者比較,差異無統計學意義(x2=0.28,P＞0.05).Smac在結節囊腫型和色素型基底細胞癌中的暘性錶達率分彆為45.28％和40.00％,二者比較,差異無統計學意義(x2=0.13,P＞ 0.05).Livin和Smac在基底細胞癌中的錶達呈負相關(r=-0.432,P＜ 0.01).結論 Livin的過錶達和Smac的低錶達可能在基底細胞癌的髮生、髮展中起一定作用.
목적 탐토조망억제단백Livin화촉조망인자Smac재기저세포암중적표체.방법 용SP법검측80례기저세포암조직중Livin화Smac적표체,분석이자표체적상관성.결과 Livin재기저세포암조직중적양성표체솔위77.50％,재정상대조조위3.33％,이자비교,차이유통계학의의(x2=49.04,P＜ 0.001).Livin재결절궤양형화색소형기저세포암중적양성표체솔분별위75.41％화80.00％,이자비교,차이무통계학의의(x2=0.001,P＞0.05).Livin재결절낭종형화색소형기저세포암중적양성표체솔분별위73.58％화80.00％,이자비교,차이무통계학의의(x2=0.03,P＞0.05).Smac재기저세포암조직중적양성표체솔위46.25％,재정상대조조위100％,이자비교,차이유통계학의의(x2=26.47,P＜0.001).Smac재결절궤양형화색소형기저세포암중적양성표체솔분별위47.54％화40.00％,이자비교,차이무통계학의의(x2=0.28,P＞0.05).Smac재결절낭종형화색소형기저세포암중적양성표체솔분별위45.28％화40.00％,이자비교,차이무통계학의의(x2=0.13,P＞ 0.05).Livin화Smac재기저세포암중적표체정부상관(r=-0.432,P＜ 0.01).결론 Livin적과표체화Smac적저표체가능재기저세포암적발생、발전중기일정작용.
Objective To detect the expression of Livin,an apoptosis-inhibiting protein,and Smac,an apoptosis-promoting protein,in basal cell carcinoma (BCC) lesions.Methods Skin specimens were obtained from the lesions of 80 patients with BCC and normal skin of 30 human controls.Immunohistochemical SP method was used to detect the pmtein expression of Livin and Smac in these specimens.Chi-square test was conducted to compare the expression rate of Livin and Smac protein between the lesional and control specimens.The relationship between the protein expression of Livin and Smac in BCC was analyzed by Spearman correlation coefficients.Results The expression rate of Livin protein was significandy higher (77.50％ vs.3.33％,x2 =49.04,P ＜ 0.001),while that of Smac protein was statistically lower (46.25％ vs.100％,x2 =26.47,P ＜ 0.001),in BCC than in the control specimens.No significant difference was observed in the expression rate of Livin or Smac protein between nodular ulcerative and pigmented BCC specimens (75.41％ vs.80.00％,x2 =0.001,P ＞ 0.05; 47.54％ vs.40.00％,x2 =0.28,P＞ 0.05) or between nodulocystic and pigmented BCC specimens (73.58％ vs.80.00％,x2 =0.03,P ＞ 0.05; 45.28％ vs.40.00％,x2 =0.13,P ＞ 0.05).There was a negative relationship between the protein expression of Livin and Smac in BCC lesions (r =-0.432,P ＜ 0.01).Conclusion The upregulated expression of Livin and downregulated expression of Smac may be invoved in the occurrence and development of BCC.
