CAJ | 학술논문

目的观察含马齿苋及青刺果提取物的医学护肤品恢复慢性湿疹患者皮肤屏障功能.方法选取慢性湿疹患者80例,其中男46例,女34例.用自身对照试验,治疗侧使用含青刺果及马齿苋的医学护肤品及糠酸莫米松乳膏,对照侧单独使用糠酸莫米松乳膏,1周后双侧停用糠酸莫米松乳膏,但治疗侧继续使用使用含青刺果及马齿苋的医学护肤品,于第0天、7天、30天、60天进行随访,通过皮肤油脂含量、角质层含水量及经表皮水分流失量(TEWL)来评估皮肤屏障功能,于第60天观察患者症状和皮损改善情况评估疗效及复发率.结果第60天,80例患者治疗侧使用医学护肤品后症状和体征改善的有效率较对照侧显著升高(P＜0.01)；复发率较对照侧显著降低(P＜ 0.01).第0天、7天、30天、60天治疗侧皮脂含量、角质层含水量较治疗前及对照侧升高,TEWL值较治疗前及对照侧降低,差异有统计学意义(P＜0.01),随着治疗时间延长,皮肤油脂含量、角质层含水量及TEWL值逐渐恢复正常.结论用含青刺果及马齿苋的医学护肤品可恢复慢性湿疹皮肤屏障功能,降低复发率.
목적 관찰함마치현급청자과제취물적의학호부품회복만성습진환자피부병장공능.방법 선취만성습진환자80례,기중남46례,녀34례.용자신대조시험,치료측사용함청자과급마치현적의학호부품급강산막미송유고,대조측단독사용강산막미송유고,1주후쌍측정용강산막미송유고,단치료측계속사용사용함청자과급마치현적의학호부품,우제0천、7천、30천、60천진행수방,통과피부유지함량、각질층함수량급경표피수분류실량(TEWL)래평고피부병장공능,우제60천관찰환자증상화피손개선정황평고료효급복발솔.결과 제60천,80례환자치료측사용의학호부품후증상화체정개선적유효솔교대조측현저승고(P＜0.01)；복발솔교대조측현저강저(P＜ 0.01).제0천、7천、30천、60천치료측피지함량、각질층함수량교치료전급대조측승고,TEWL치교치료전급대조측강저,차이유통계학의의(P＜0.01),수착치료시간연장,피부유지함량、각질층함수량급TEWL치축점회복정상.결론 용함청자과급마치현적의학호부품가회복만성습진피부병장공능,강저복발솔.
Objective To evaluate the restoring effect of a skin care product containing Prinsepia utilis Royle and purslane on skin barrier function in patients with chronic eczema.Methods Eighty patients with chronic eczema,including 46 males and 34 females,were recruited in this study.A self-controlled study was performed.Lesions on one body side of the patients (experiment side) were topically treated with a skin care product containing Prinsepia utilis Royle and purslane in combination with mometasone furoate cream once daily,and those on the other body side (control side) treated with mometasone furoate cream alone once daily.Mometasone furoate cream was applied for one week in both sides,and the skin care product for 60 days in the experiment side.Patients visited the hospital on day 0,7,30 and 60 after the beginning of treatment.Skin barrier function was evaluated by skin sebum content,stratum corneum hydration and transepidermal water loss (TEWL).The improvement of signs and symptoms was estimated in patients at the end of the treatment (on day 60).Results At the end of the 60-day treatment,the experiment side showed significantly higher response rate but lower recurrence rate compared with the control side (all P ＜ 0.01).Moreover,skin sebum content and stratum corneum hydration significantly increased,but TEWL value statistically decreased in the experiment side on day 7,30 and 60 compared with those in the same side on day 0 as well as those in the control side at these same time points (all P ＜ 0.01).After the start of treatment,skin sebum content,stratum corneum hydration and TEWL value gradually restored to the normal levels over time in the experiment side.Conclusion The skin care product containing Prinsepia utilis Royle and purslane can effectively restore skin barrier function in,and decrease the recurrence of,eczema.