中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2014年
1期
48-50
,共3页
李水凤%张小婷%戚世玲%叶艳婷%曹慧%杨雨清%章星琪
李水鳳%張小婷%慼世玲%葉豔婷%曹慧%楊雨清%章星琪
리수봉%장소정%척세령%협염정%조혜%양우청%장성기
斑秃%过敏反应%尘螨科%蜚蠊目
斑禿%過敏反應%塵螨科%蜚蠊目
반독%과민반응%진만과%비렴목
Alopecia areata%Anaphylaxis%Pyroglyphidae%Cockroaches
目的 探讨232例斑秃患者的临床特征、伴发过敏性疾病的情况及血清中总IgE和特异性免疫球蛋白E(sIgE)的水平以及它们之间的相互关系.方法 免疫比浊法和荧光酶联免疫吸附法分别检测232例斑秃患者血清中的总IgE及常见过敏原的sIgE.110例健康对照来自体检中心.结果 232例斑秃患者中,男127例,女105例,平均(26.4±13.8)岁,平均病程(25.3±42.3)个月,89例(38.4％)为重型斑秃.67例(28.9％)除患斑秃外,还伴发至少1种过敏性疾病,但血清总IgE阳性率(30.6％)与健康对照组(21.8％)相比,差异无统计学意义.斑秃患者sIgE升高以户尘螨(34.1％)、粉尘螨(31.9％)、蟑螂(22.5％)为主,均为常见过敏原,且三者sIgE的水平分别与总IgE水平呈正相关关系.户尘螨、蟑螂sIgE的阳性率和水平与健康对照组比较,差异无统计学意义.在重型、弥漫型斑秃中,户尘螨、蟑螂sIgE和儿童斑秃户尘螨sIgE的阳性率和水平均比健康对照组高,差异有统计学意义.重型患者户尘螨、蟑螂sIgE或儿童斑秃户尘螨sIgE阳性率和水平,各自比轻型或成人斑秃患者为高,差异有统计学意义.结论 尘螨过敏是部分斑秃患者(重型、弥漫型及儿童斑秃)的发病因素之一,也是斑秃患者中发病早、脱发范围广的危险因素之一.
目的 探討232例斑禿患者的臨床特徵、伴髮過敏性疾病的情況及血清中總IgE和特異性免疫毬蛋白E(sIgE)的水平以及它們之間的相互關繫.方法 免疫比濁法和熒光酶聯免疫吸附法分彆檢測232例斑禿患者血清中的總IgE及常見過敏原的sIgE.110例健康對照來自體檢中心.結果 232例斑禿患者中,男127例,女105例,平均(26.4±13.8)歲,平均病程(25.3±42.3)箇月,89例(38.4％)為重型斑禿.67例(28.9％)除患斑禿外,還伴髮至少1種過敏性疾病,但血清總IgE暘性率(30.6％)與健康對照組(21.8％)相比,差異無統計學意義.斑禿患者sIgE升高以戶塵螨(34.1％)、粉塵螨(31.9％)、蟑螂(22.5％)為主,均為常見過敏原,且三者sIgE的水平分彆與總IgE水平呈正相關關繫.戶塵螨、蟑螂sIgE的暘性率和水平與健康對照組比較,差異無統計學意義.在重型、瀰漫型斑禿中,戶塵螨、蟑螂sIgE和兒童斑禿戶塵螨sIgE的暘性率和水平均比健康對照組高,差異有統計學意義.重型患者戶塵螨、蟑螂sIgE或兒童斑禿戶塵螨sIgE暘性率和水平,各自比輕型或成人斑禿患者為高,差異有統計學意義.結論 塵螨過敏是部分斑禿患者(重型、瀰漫型及兒童斑禿)的髮病因素之一,也是斑禿患者中髮病早、脫髮範圍廣的危險因素之一.
목적 탐토232례반독환자적림상특정、반발과민성질병적정황급혈청중총IgE화특이성면역구단백E(sIgE)적수평이급타문지간적상호관계.방법 면역비탁법화형광매련면역흡부법분별검측232례반독환자혈청중적총IgE급상견과민원적sIgE.110례건강대조래자체검중심.결과 232례반독환자중,남127례,녀105례,평균(26.4±13.8)세,평균병정(25.3±42.3)개월,89례(38.4％)위중형반독.67례(28.9％)제환반독외,환반발지소1충과민성질병,단혈청총IgE양성솔(30.6％)여건강대조조(21.8％)상비,차이무통계학의의.반독환자sIgE승고이호진만(34.1％)、분진만(31.9％)、장랑(22.5％)위주,균위상견과민원,차삼자sIgE적수평분별여총IgE수평정정상관관계.호진만、장랑sIgE적양성솔화수평여건강대조조비교,차이무통계학의의.재중형、미만형반독중,호진만、장랑sIgE화인동반독호진만sIgE적양성솔화수평균비건강대조조고,차이유통계학의의.중형환자호진만、장랑sIgE혹인동반독호진만sIgE양성솔화수평,각자비경형혹성인반독환자위고,차이유통계학의의.결론 진만과민시부분반독환자(중형、미만형급인동반독)적발병인소지일,야시반독환자중발병조、탈발범위엄적위험인소지일.
Objective To analyze the clinical features of,concurrence of allergic diseases in,as well as serum levels of total immunoglobulin E (IgE) and specific IgEs in,232 patients with alopecia areata (AA),and to estimate their relationship.Methods Serum samples were obtained from 232 patients with AA and 110 healthy controls from a health check-up center.Turbidimetric immunoassay and fluorescence-based enzyme-linked immunosorbent assay were performed to measure total IgE and specific IgEs to common antigens in these serum samples,respectively.Statistical analysis was carried out by t test,rank sum test,and chi-square test.Results The patients showed a male/female ratio of 127 ∶ 105 with an average age of (26.4 ± 13.8) years and clinical course of (25.3 ± 42.3) months.Among these patients,89 (38.4％) suffered from severe AA,and 67 (28.9％) reported at least one allergic disease.No significant difference was found in the positive rates of serum total IgE (30.2％ vs.21.8％,P ＞ 0.05),anti-Dermatophagoides pteronyssinus and-Cockroach specific IgEs or the serum levels of antiDermatophagoides pteronyssinus or-Cockroach IgE between the patients and healthy controls.The three most common specific IgEs were anti-Dermatophagoides pteronyssinus IgE (34.1％),anti-Dermatophagoides farinae IgE (31.9％) and anti-Cockroach IgE (22.5％) in patients with AA,whose serum levels were positively correlated with the level of serum total IgE separately.A significant increase was observed in the positive rates and serum levels of anti-Dermatophagoides pteronyssinus and-Cockroach specific IgEs in patients with severe and diffuse AA compared with the healthy controls and patients with mild AA,as well as in those of anti-Dermatophagoides pteronyssinus specific IgE in child patients with AA compared with the healthy controls and adult patients with AA (P ＜ 0.05 or 0.01).Conclusions Dust mite allergy may be not only a pathogenic factor for severe,diffuse and childhood AA,but also a risk factor for early onset and severe type of AA.
