中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2014年
4期
281-283
,共3页
苏惠春%程波%刘晶晶%王育英
囌惠春%程波%劉晶晶%王育英
소혜춘%정파%류정정%왕육영
痤疮,寻常%物理治疗技术%高温,诱发%随机对照试验
痤瘡,尋常%物理治療技術%高溫,誘髮%隨機對照試驗
좌창,심상%물리치료기술%고온,유발%수궤대조시험
Acne vulgaris%Physical therapy modalities%Hyperthermia,induced%Randomized controlled trials
目的 评价粉刺治疗仪治疗寻常痤疮的疗效和安全性.方法 73例轻中度寻常痤疮患者,采用双中心随机单盲自身阴性对照平行试验方法,从每例患者面部取2个类似的炎性丘疹,分别用粉刺治疗仪(输出温度为46℃～50℃)和无热源的安慰仪器进行治疗(分别为治疗组和对照组),共治疗3次,每次3 min,头2次在第1天,2次间隔1自12h,第3次在第2天,与上1次治疗间隔18 ～48 h.于治疗前、开始后第1、5和14天分别记录受试者两个皮损的颜色、直径、不良反应等,并对每个皮损进行评分,比较治疗结果.结果 治疗组73例治疗后第1、5和14天分别有66例(90.4％)、73例(100.0％)、72例(98.6％)有效,27例(37.0％)、64例(87.7％)、72例(98.6％)显效,与对照组有效率和显效率比较,差异均有统计学意义.治疗组皮损红肿开始消退的平均时间为19.51 h,比对照组提前82.41 h;治疗组完全痊愈的平均时间为7.15 d,比对照组提前5.07 d.结论 粉刺治疗仪治疗轻中度痤疮安全有效,可快速缓解炎症痤疮症状,缩短皮损红肿消退时间和皮损痊愈时间.
目的 評價粉刺治療儀治療尋常痤瘡的療效和安全性.方法 73例輕中度尋常痤瘡患者,採用雙中心隨機單盲自身陰性對照平行試驗方法,從每例患者麵部取2箇類似的炎性丘疹,分彆用粉刺治療儀(輸齣溫度為46℃～50℃)和無熱源的安慰儀器進行治療(分彆為治療組和對照組),共治療3次,每次3 min,頭2次在第1天,2次間隔1自12h,第3次在第2天,與上1次治療間隔18 ～48 h.于治療前、開始後第1、5和14天分彆記錄受試者兩箇皮損的顏色、直徑、不良反應等,併對每箇皮損進行評分,比較治療結果.結果 治療組73例治療後第1、5和14天分彆有66例(90.4％)、73例(100.0％)、72例(98.6％)有效,27例(37.0％)、64例(87.7％)、72例(98.6％)顯效,與對照組有效率和顯效率比較,差異均有統計學意義.治療組皮損紅腫開始消退的平均時間為19.51 h,比對照組提前82.41 h;治療組完全痊愈的平均時間為7.15 d,比對照組提前5.07 d.結論 粉刺治療儀治療輕中度痤瘡安全有效,可快速緩解炎癥痤瘡癥狀,縮短皮損紅腫消退時間和皮損痊愈時間.
목적 평개분자치료의치료심상좌창적료효화안전성.방법 73례경중도심상좌창환자,채용쌍중심수궤단맹자신음성대조평행시험방법,종매례환자면부취2개유사적염성구진,분별용분자치료의(수출온도위46℃～50℃)화무열원적안위의기진행치료(분별위치료조화대조조),공치료3차,매차3 min,두2차재제1천,2차간격1자12h,제3차재제2천,여상1차치료간격18 ～48 h.우치료전、개시후제1、5화14천분별기록수시자량개피손적안색、직경、불량반응등,병대매개피손진행평분,비교치료결과.결과 치료조73례치료후제1、5화14천분별유66례(90.4％)、73례(100.0％)、72례(98.6％)유효,27례(37.0％)、64례(87.7％)、72례(98.6％)현효,여대조조유효솔화현효솔비교,차이균유통계학의의.치료조피손홍종개시소퇴적평균시간위19.51 h,비대조조제전82.41 h;치료조완전전유적평균시간위7.15 d,비대조조제전5.07 d.결론 분자치료의치료경중도좌창안전유효,가쾌속완해염증좌창증상,축단피손홍종소퇴시간화피손전유시간.
Objective To evaluate the efficacy and safety of an acne-clearing device in treating acne vulgaris.Methods A bicenter,randomized,single-blinded,placebo-controlled,parallel-group study was conducted.Seventy-three patients with mild to moderate acne vulgaris were enrolled for the trial.Two similar,clinically matched inflammatory papules were selected from each patient,and divided into a test group and a control group to be treated with an acne-clearing device with an output temperature of 46-50 ℃ and a control device without heat source respectively,for three sessions with the interval varying from 1 to 12 hours between the first two sessions and from 18 to 48 hours between the last two sessions.Every treatment lasted three minutes.Lesional color and size were recorded before and on day 1,5 and 14 after the first treatment.Side effects were also recorded for the evaluation of safety.Results Clinical improvement was observed in 66 (90.4％),73 (100.0％) and 72 (98.6％) patients,and marked improvement in 27 (37.0％),64 (87.7％) and 72 (98.6％) patients on day 1,5 and 14 after the first treatment,respectively.Significant differences existed between the control and test group in improvement rate on day 1 and 5,and in marked improvement rate on all the three time points (all P ＜ 0.01).The average time taken for erythematous swelling to begin to subside and time for lesions to completely heal were 19.51 hours and 7.15 days respectively in the test group,significantly shorter than those in the control group by 82.41 hours and 5.07 days respectively.Conclusions The acne-clearing device proves to be effective and safe for the treatment of mild to moderate acne vulgaris,which can rapidly relieve the inflammation in acne,shorten the time required for erythematous swelling to subside and for lesions to completely heal.
