CAJ | 학술논문

目的探讨急性时相反应、凝血/纤溶系统与慢性荨麻疹的关系.方法用酶联免疫吸附法测定53例慢性荨麻疹患者及25例健康人血清白介素6(IL-6)、淀粉样A物质(SAA)水平,同时用免疫比浊法测定血清超敏C反应蛋白(Hs-CRP)及血浆D-二聚体水平,比较两组之间的差异.慢性荨麻疹患者按症状严重程度分为3级(3组),分析各检测项目之间的相关性以及各检测项目与慢性荨麻疹症状严重程度的关系.结果慢性荨麻疹患者组IL-6(10.70±4.94 ng/L)、SAA[M(P25,P75)为4.92(8.22,12.51) μg/L]、D-二聚体(222.32±163.69 μg/L)水平均高于健康对照组[分别为7.49±3.41 ng/L、2.11 (1.21,2.83) μg/L、104.72±43.12 μg/L],两组差异均有统计学意义(P＜0.05);Hs-CRP水平[0.30(0.l0,1.40) mg/L]与健康对照组[0.30(0.10,0.55) mg/L]比较,差异无统计学意义(P＞0.05).慢性荨麻疹患者IL-6水平与Hs-CRP、SAA、D-二聚体水平及症状严重程度均无显著相关性(均P＞ 0.05),Hs-CRP水平与SAA水平(r=0.67,P＜ 0.01)、Hs-CRP水平与D-二聚体水平(r=0.49,P＜ 0.01)、SAA水平与D-二聚体水平(r=0.38,P＜ 0.01)均呈显著正相关;Hs-CRP、SAA、D-二聚体水平与症状严重程度呈显著正相关(r值分别为0.63、0.62、0.47,均P＜0.01).结论慢性荨麻疹患者存在急性时相反应及凝血系统的激活,两者的发生可能存在相关性.
목적 탐토급성시상반응、응혈/섬용계통여만성담마진적관계.방법 용매련면역흡부법측정53례만성담마진환자급25례건강인혈청백개소6(IL-6)、정분양A물질(SAA)수평,동시용면역비탁법측정혈청초민C반응단백(Hs-CRP)급혈장D-이취체수평,비교량조지간적차이.만성담마진환자안증상엄중정도분위3급(3조),분석각검측항목지간적상관성이급각검측항목여만성담마진증상엄중정도적관계.결과 만성담마진환자조IL-6(10.70±4.94 ng/L)、SAA[M(P25,P75)위4.92(8.22,12.51) μg/L]、D-이취체(222.32±163.69 μg/L)수평균고우건강대조조[분별위7.49±3.41 ng/L、2.11 (1.21,2.83) μg/L、104.72±43.12 μg/L],량조차이균유통계학의의(P＜0.05);Hs-CRP수평[0.30(0.l0,1.40) mg/L]여건강대조조[0.30(0.10,0.55) mg/L]비교,차이무통계학의의(P＞0.05).만성담마진환자IL-6수평여Hs-CRP、SAA、D-이취체수평급증상엄중정도균무현저상관성(균P＞ 0.05),Hs-CRP수평여SAA수평(r=0.67,P＜ 0.01)、Hs-CRP수평여D-이취체수평(r=0.49,P＜ 0.01)、SAA수평여D-이취체수평(r=0.38,P＜ 0.01)균정현저정상관;Hs-CRP、SAA、D-이취체수평여증상엄중정도정현저정상관(r치분별위0.63、0.62、0.47,균P＜0.01).결론 만성담마진환자존재급성시상반응급응혈계통적격활,량자적발생가능존재상관성.
Objective To evaluate the relationship of acute-phase response and coagulation/fibrinolysis with chronic urticaria (CU).Methods Fifty-three patients with CU and twenty-five healthy human controls were enrolled in this study.Venous blood samples were collected from all of these subjects.Then,enzyme-linked immunosorbent assay was carried out to measure the serum levels of interleukin-6 (IL-6) and amyloid protein A (AA),and immunoturbidimetry to determine the levels of serum high sensitive C-reactive protein (Hs-CRP) and plasma D-dimer.The patients with CU were classified into three groups according to the severity of clinical symptoms.The levels of serum IL-6 and plasma D-dimer were given in mean ± standard deviation,and those of serum AA and Hs-CRP in mean (25th percentile,75th percentile).Rank sum test and t test were performed to compare these parameters between the patients and controls,and Spearman rank correlation analysis was conducted to study the relationship among these parameters as well as between these parameters and symptom severity in these patients.Results The levels of serum IL-6,serum AA and plasma D-dimer were (10.70 ± 4.94) ng/L,4.92 (8.22,12.51) μg/L,and (222.32 ± 163.69) μg/L respectively in the patients with CU,significantly higher than those in the healthy controls ((7.49 ± 3.41) ng/L,2.11 (1.21,2.83) μg/L,(104.72 ± 43.12) μg/L,respectively,all P＜ 0.05),while no significant differences were observed between the patients and controls in the level of serum HsCRP (0.30 (0.10,1.40) mg/L vs.0.30 (0.10,0.55) mg/L,P ＞ 0.05).In patients with CU,the levels of serum IL-6 were unrelated to those of serum Hs-CRP,serum AA,or plasma D-dimer (all P ＞ 0.05),whereas a positive correlation was observed between the levels of serum Hs-CRP and AA (r =0.67,P ＜ 0.01),serum Hs-CRP and plasma D-dimer (r =0.49,P ＜ 0.01),serum AA and plasma D-dimer (r =0.38,P ＜ 0.01).Further more,the levels of serum Hs-CRP,AA and plasma D-dimer were significantly correlated with symptom severity in patients with CU (r =0.63,0.62,0.47,respectively,all P ＜ 0.01).Conclusions Acute-phase response coexists with the activation of coagulation system in patients with CU,suggesting a potential association between acute-phase response and coagulation system activation.