中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2014年
9期
667-668
,共2页
皮肤色素沉着%色素减退%病理过程
皮膚色素沉著%色素減退%病理過程
피부색소침착%색소감퇴%병리과정
Skin pigmentation%Hypopigmentation%Pathological processes
目的 探讨弥漫性色素沉着伴点状色素减退的临床特点及诊断要点.方法 回顾分析2005-2012年收治的10例弥漫性色素沉着伴点状色素减退患者的临床表现,病理特征及转归.结果 10例患者中,男6例,女4例;其中成年患者3例,中位发病年龄7岁(4 ～ 25岁),所有患者均无家族史.典型临床表现为弥漫、均匀的色素沉着基础上发生密集点状白斑.皮损可累及全身,无自行消退趋势.组织学均表现为表皮基底层色素略深,真皮浅层血管周围散在色素颗粒和噬色素细胞.部分基底层可见灶性空泡变性.结论 弥漫性色素沉着伴点状色素减退是一种少见的色素沉着和色素减退伴发的色素异常性疾病,常见于儿童,病理表现为炎症后色素沉着.皮损一旦发生,无消退趋势,目前尚无有效治疗方法.
目的 探討瀰漫性色素沉著伴點狀色素減退的臨床特點及診斷要點.方法 迴顧分析2005-2012年收治的10例瀰漫性色素沉著伴點狀色素減退患者的臨床錶現,病理特徵及轉歸.結果 10例患者中,男6例,女4例;其中成年患者3例,中位髮病年齡7歲(4 ～ 25歲),所有患者均無傢族史.典型臨床錶現為瀰漫、均勻的色素沉著基礎上髮生密集點狀白斑.皮損可纍及全身,無自行消退趨勢.組織學均錶現為錶皮基底層色素略深,真皮淺層血管週圍散在色素顆粒和噬色素細胞.部分基底層可見竈性空泡變性.結論 瀰漫性色素沉著伴點狀色素減退是一種少見的色素沉著和色素減退伴髮的色素異常性疾病,常見于兒童,病理錶現為炎癥後色素沉著.皮損一旦髮生,無消退趨勢,目前尚無有效治療方法.
목적 탐토미만성색소침착반점상색소감퇴적림상특점급진단요점.방법 회고분석2005-2012년수치적10례미만성색소침착반점상색소감퇴환자적림상표현,병리특정급전귀.결과 10례환자중,남6례,녀4례;기중성년환자3례,중위발병년령7세(4 ～ 25세),소유환자균무가족사.전형림상표현위미만、균균적색소침착기출상발생밀집점상백반.피손가루급전신,무자행소퇴추세.조직학균표현위표피기저층색소략심,진피천층혈관주위산재색소과립화서색소세포.부분기저층가견조성공포변성.결론 미만성색소침착반점상색소감퇴시일충소견적색소침착화색소감퇴반발적색소이상성질병,상견우인동,병리표현위염증후색소침착.피손일단발생,무소퇴추세,목전상무유효치료방법.
Objective To assess the clinical feature and diagnosis of diffuse hyperpigmentation with guttate depigmentation macules.Methods A retrospective study was carried out among 10 patients with diffuse hyperpigmentation with guttate depigmentation macules collected at the Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College from 2005 to 2012.The clinical manifestations,pathological findings and disease outcomes in these patients were analyzed.Results Of the 10 patients,6 were male,and 4 were female.The median age at onset was 7 years (range,4-25),and there were only 3 adult patients among these patients.None of the patients had a family history of pigmentary disturbance.Typical clinical manifestations included densely distributed,guttate hypopigmented macules arising on diffuse and uniform hyperpigmentation.Lesions could slowly spread over the body surface without the trend towards spontaneous regression.Pathologically,there was a slight increase in pigmentation of the epidermal basal layer,as well as melanins and melanophages scattered around blood vessels in the superficial dermis,with or without focal vacuolar degeneration of the basal cell layer.Conclusions Diffuse hyperpigmentation with guttate depigmentation macules,a rare pigmentary disturbance that clinically manifests as both hyperpigmentation and hypopigmentation and is pathologically characterized by postinflammatory hyperpigmentation,often affects children.Once the lesions occur,there is no trend towards regression.No effective treatment is available for this entity at present.
