CAJ | 학술논문

目的探讨白癜风自体培养黑素细胞移植疗效与白细胞介素17、Foxp3的相关性.方法对40例稳定期寻常型白癜风患者进行自体培养黑素细胞移植,同时收集其外周血,6个月后根据移植效果将收集的血液分为成功组25例,失败组15例.用ELISA的方法测定移植成功与移植失败外周血中白细胞介素17及Foxp3水平,比较移植成功组与失败组血清中白细胞介素17及Foxp3水平的差异.用SPSS 17.0统计软件进行统计分析.结果移植成功组血清中白细胞介素17(15.29±7.86) ng/L,明显低于移植失败组(43.88±13.02) ng/L,差异有统计学意义.血清中Foxp3的水平,移植成功组(6.08±2.03) ng/L,高于移植失贮组(3.37±1.81) ng/L,两者之间比较,差异有统计学意义.结论血清白细胞介素17水平升高、Foxp3水平降低与白癜风患者的移植失败有相关性.
목적 탐토백전풍자체배양흑소세포이식료효여백세포개소17、Foxp3적상관성.방법 대40례은정기심상형백전풍환자진행자체배양흑소세포이식,동시수집기외주혈,6개월후근거이식효과장수집적혈액분위성공조25례,실패조15례.용ELISA적방법측정이식성공여이식실패외주혈중백세포개소17급Foxp3수평,비교이식성공조여실패조혈청중백세포개소17급Foxp3수평적차이.용SPSS 17.0통계연건진행통계분석.결과 이식성공조혈청중백세포개소17(15.29±7.86) ng/L,명현저우이식실패조(43.88±13.02) ng/L,차이유통계학의의.혈청중Foxp3적수평,이식성공조(6.08±2.03) ng/L,고우이식실저조(3.37±1.81) ng/L,량자지간비교,차이유통계학의의.결론 혈청백세포개소17수평승고、Foxp3수평강저여백전풍환자적이식실패유상관성.
Objective To investigate the relationship between the efficacy of autologous cultured melanocyte transplantation and serum levels of interleukin-17 (IL-17) and FoxP3 in patients with vitiligo.Methods Forty patients with stable vitiligo vulgaris were included in this study,and received autologous cultured melanocyte transplantation.Six months after the transplantation,treatment efficacy was evaluated,and patients were classified into the successfully treated group (n =25) and unsuccessfully treated group (n =15).Peripheral blood was collected from all the patients before the transplantation,and enzyme-linked immunosorbent assay (ELISA) was performed to measure the serum levels of IL-17 and FoxP3.Statistical analysis was done using two independent samples t-test with the SPSS software (version 17.0).Results The successfully treated patients showed lower serum levels of IL-17 ((15.29 ± 7.86) vs.(43.88 ± 13.02) ng/L,P ＜ 0.05),but higher serum levels of FoxP3 ((6.08 ± 2.03) vs.(3.37 ± 1.81) ng/L,P ＜ 0.05) than the unsuccessfully treated patients.Conclusion The increased serum IL-17 and decreased serum FoxP3 may contribute to the failure of autologous cultured melanocyte transplantation in patients with vitiligo.