CAJ | 학술논문

目的探讨白癜风与IL-17的相关性.方法酶联免疫吸附测定法对32例白癜风患者和30例健康对照组外周血血浆IL-17含量进行检测,分析IL-17水平与白癜风患者不同分期、面积、病程的关系.结果进展期和稳定期白癜风患者血浆IL-17含量与健康对照组相比明显升高(均P＜0.05),且进展期明显高于稳定期(P＜ 0.05);IL-17水平与皮损面积呈正相关(r=0.456,P＜0.05),与病程无相关(r=0.239,P＞ 0.05).结论 IL-17在白癜风的发生发展过程中起到一定作用.
목적 탐토백전풍여IL-17적상관성.방법 매련면역흡부측정법대32례백전풍환자화30례건강대조조외주혈혈장IL-17함량진행검측,분석IL-17수평여백전풍환자불동분기、면적、병정적관계.결과 진전기화은정기백전풍환자혈장IL-17함량여건강대조조상비명현승고(균P＜0.05),차진전기명현고우은정기(P＜ 0.05);IL-17수평여피손면적정정상관(r=0.456,P＜0.05),여병정무상관(r=0.239,P＞ 0.05).결론 IL-17재백전풍적발생발전과정중기도일정작용.
Objective To investigate the relationship between interleukin-17 (IL-17) and vitiligo.Methods Totally,32 vitiligo patients and 30 healthy human controls were enrolled in this study.Blood samples were collected from all the subjects,and enzyme-linked immunosorbent assay (ELISA) was performed to determine the plasma levels of IL-17.The relationship of plasma IL-17 levels with disease stage,clinical course and lesion area was assessed.Results The plasma levels of IL-17 were significantly higher in the patients with progressive and stable vitiligo than in the healthy controls (both P ＜ 0.05),and higher in the patients with progressive vitiligo than in those with stable vitiligo (P ＜ 0.05).Moreover,the plasma levels of IL-17 were positively correlated with the area of vitiligo lesions (r =0.456,P ＜ 0.05),but unrelated to the clinical course of vitiligo (r =0.239,P ＞ 0.05).Conclusion IL-17 may play a certain role in the occurrence and development of vitiligo.