CAJ | 학술논문

目的分析Th17细胞与斑秃病程、病情等的关系.方法分别抽取斑秃组和健康对照组的外周血,流式细胞仪检测Th17细胞的比例,用SPSS16.0进行统计分析.结果斑秃组60例外周血中Th17细胞占CD4+T细胞的比例(1.33％±0.74％)显著高于30例健康对照组(0.91％±0.54％,P＜ 0.01).初发斑秃患者Th17细胞比例显著高于复发患者(P＜0.05),活动期高于非活动期(P＜0.05),病程≤6个月者高于病程＞6个月者(P＜0.01),而头皮脱发面积≤50％者与脱发面积＞50％及全秃和普秃者比较差异无统计学意义.结论外周血Th17细胞的水平与斑秃活动性、疾病复发及病程有关.
목적 분석Th17세포여반독병정、병정등적관계.방법 분별추취반독조화건강대조조적외주혈,류식세포의검측Th17세포적비례,용SPSS16.0진행통계분석.결과 반독조60예외주혈중Th17세포점CD4+T세포적비례(1.33％±0.74％)현저고우30례건강대조조(0.91％±0.54％,P＜ 0.01).초발반독환자Th17세포비례현저고우복발환자(P＜0.05),활동기고우비활동기(P＜0.05),병정≤6개월자고우병정＞6개월자(P＜0.01),이두피탈발면적≤50％자여탈발면적＞50％급전독화보독자비교차이무통계학의의.결론 외주혈Th17세포적수평여반독활동성、질병복발급병정유관.
Objective To investigate the relationship of peripheral blood T helper type 17 (Th17) cells with the clinical course and severity of alopecia areata (AA).Methods Peripheral blood samples were obtained from 60 patients with AA and 30 healthy human controls.Flow cytometry was performed to determine the proportion of Th 17 subsets in these samples.Statistical analysis was done by two independent samples t-test with SPSS software version 16.0.Results The proportion of Th17 subsets in peripheral blood CD4+ T cells was significantly higher in the AA patients than in the healthy controls (1.33％ ± 0.74％ vs.0.91％ ± 0.54％,P ＜ 0.01),higher in patients with initial AA than in those with recurrent AA (P ＜ 0.05),higher in patients with active AA than in those with inactive AA (P ＜ 0.05),higher in patients with a clinical course of ＜ or =6 months than in those ＞ 6 months (P ＜ 0.01).No significant difference was observed in the proportion of peripheral blood Th17 cells between patients with AA involving no more than 50％ of the scalp and those with AA involving more than 50％ of the scalp,alopecia totalis or alopecia universalis (P ＞ 0.05).Conclusion The level of peripheral blood Th17 cells is associated with the activity,relapse,and clinical course of AA.