CAJ | 학술논문

目的探讨乳腺浸润性筛状癌(invasive cribriform carcinoma,ICC)的临床病理特征及治疗方式.方法收集24例乳腺ICC的临床病理资料,对其组织学形态及免疫组化特征进行研究,并通过随访研究其预后.结果全组患者均为女性,中位发病年龄48岁；肿物平均最大径3.1cm；病理学特点:癌细胞成筛孔状排列,但筛孔形状较不规则,细胞分化较好,体积较小,未见核分裂象,间质可出现反应性增生；雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)阳性表达率较高(均为79.2％),人类表皮生长因子受体2(human epithelial growth factor receptor 2,C-erbB-2)阳性表达率较低(4.1％)；患者预后极佳,复发转移少见,5年生存率达100％.结论乳腺ICC组织学形态结构独特,复发转移率较低,预后良好,治疗应有别于一般的浸润性乳腺癌.
목적 탐토유선침윤성사상암(invasive cribriform carcinoma,ICC)적림상병리특정급치료방식.방법 수집24례유선ICC적림상병리자료,대기조직학형태급면역조화특정진행연구,병통과수방연구기예후.결과 전조환자균위녀성,중위발병년령48세；종물평균최대경3.1cm；병이학특점:암세포성사공상배렬,단사공형상교불규칙,세포분화교호,체적교소,미견핵분렬상,간질가출현반응성증생；자격소수체(estrogen receptor,ER)、잉격소수체(progesterone receptor,PR)양성표체솔교고(균위79.2％),인류표피생장인자수체2(human epithelial growth factor receptor 2,C-erbB-2)양성표체솔교저(4.1％)；환자예후겁가,복발전이소견,5년생존솔체100％.결론 유선ICC조직학형태결구독특,복발전이솔교저,예후량호,치료응유별우일반적침윤성유선암.
Objective To study the clinicopathological characteristics and therapeutics of invasive cribriform carcinoma(ICC) of the breast.Methods We enrolled 24 cases of breast invasive cribriform cancer out of invasive breast cancer patients according to the 2012 WHO Classification of Tumours of the Breast.The clinical and pathological data were collected and reviewed,the morphological and immunohistochemical characteristics were measured,and the prognosis was observed through follow-up.Results All the patients were female,median age was 48 years old and the mean maximum diameter of the tumor was 3.1 cm.Histologically,cancer cells arranged in cribriform manner with irregular shape,the cancer cells were small and had higher differentiation degree,no mitotic figure,reactive hyperplasia was visible in mesenchyme.Estrogen receptor(ER) and progesterone recepter (PR)were positive in 79.2％,but the positive expression rate of C-erbB-2 was low (4.1％) ; Patients with ICC of the breast have excellent prognosis,with very low relapse and metastasis,five-year survival rate was 100％.Conclusions Breast invasive cribriform carcinoma is a disease of unique histological morphology,low rate of recurrence and metastasis,and a good prognosis.