CAJ | 학술논문

回顾性分析北京协和医院12例慢性活动性EB病毒感染患者的临床资料.其中男7例,女5例；发病年龄平均28岁；均无明确免疫缺陷的基础病.临床表现主要为发热、肝脾大、淋巴结肿大等.辅助检查多为肝功能和血液学异常等.所有患者均有外周血EB病毒载量的明显增高[(1.7×103～3.5×107)copies/μg DNA].12例中5例死亡,2例失访,1例发生T细胞淋巴瘤.提示慢性活动性EB病毒感染是一种少见但严重的疾病,应引起临床医师的关注.
회고성분석북경협화의원12례만성활동성EB병독감염환자적림상자료.기중남7례,녀5례；발병년령평균28세；균무명학면역결함적기출병.림상표현주요위발열、간비대、림파결종대등.보조검사다위간공능화혈액학이상등.소유환자균유외주혈EB병독재량적명현증고[(1.7×103～3.5×107)copies/μg DNA].12례중5례사망,2례실방,1례발생T세포림파류.제시만성활동성EB병독감염시일충소견단엄중적질병,응인기림상의사적관주.
The medical records of all 12 patients diagnosed as chronic active Epstein-Barr virus (CAEBV) infection at our hospital were analyzed retrospectively.There were 7 males and 5 females with a median onset age of 28 years.CAEBV was characterized by fever,splenomegaly,hepatomegaly and lymphadenopathy,etc.The abnormalities of laboratory examination included liver dysfunction,thrombocytopenia,anemia and leucopenia.EBV-DNA detected by real-time polymerase chain reaction was (1.7 × 103-3.5 × 107) copies/μg DNA in peripheral blood mononuclear cell.Among them,the outcomes were death (n =5),lost to follow-up (n =2) and T cell lymphoma (n =1).It is necessary to improve our awareness of CAEBV infection because of its poor prognosis and high mortality.