CAJ | 학술논문

选取2006年5月至2012年3月应用含标准剂量5-氟尿嘧啶方案化疗住院患者116例,分为观察组(39例)、治疗组(41例)和空白组(36例).观察组化疗同步静脉应用异甘草酸镁100mg/d,治疗组应用还原型谷胱甘肽1.2 g/d,空白组不用任何保肝药物.化疗后1周复查并比较3组患者肝功能指标.观察组患者肝功能全部指标变化无统计学意义(P＞0.05),治疗组和空白组患者部分肝功能指标变化差异有统计学意义(P＜0.05).异甘草酸镁在含5-氟尿嘧啶方案化疗过程中可对患者肝功能有保护作用.
선취2006년5월지2012년3월응용함표준제량5-불뇨밀정방안화료주원환자116례,분위관찰조(39례)、치료조(41례)화공백조(36례).관찰조화료동보정맥응용이감초산미100mg/d,치료조응용환원형곡광감태1.2 g/d,공백조불용임하보간약물.화료후1주복사병비교3조환자간공능지표.관찰조환자간공능전부지표변화무통계학의의(P＞0.05),치료조화공백조환자부분간공능지표변화차이유통계학의의(P＜0.05).이감초산미재함5-불뇨밀정방안화료과정중가대환자간공능유보호작용.
A total of 116 hospitalized patients between May 2006 and March 2012 were divided into observation(n =39),treatment control (n =41) and blank control group (n =36).All groups received standard doses of chemotherapy with 5-fluorouracil.Patients in observation group received a daily intravenous infusion of 100 mg magnesium isoglycyrrhizinate plus chemotherapy while those in the treatment control group a daily 1.2 g reduced glutathione intravenous infusion plus chemotherapy.And the blank control group accepted chemotherapy alone.The parameters of liver function,including aspartate aminotransferase,alkaline phosphatase,gamma glutamyl transferase,lactate dehydrogenase,total bilirubin and albumin,were recorded and compared at Week 1.No significantly difference in the above parameters was found in observation group(P ＞ 0.05).However,in treatment control and blank control groups,significant statistical differences existed in some of the parameters (P ＜ 0.05).Magnesium Isoglycyrrhizinate is an efficient protector of liver function for patients on chemotherapy with 5-fluorouracil.