CAJ | 학술논문

采用胸腔循环热灌注化疗方法治疗55例恶性胸腔积液患者,完全缓解23例(41.8％),局部缓解25例(45.5％),稳定4例(7.3％),进展3例(5.5％),有效率87.3％.治疗后胸腔积液IL-10、IL-6水平较治疗前显著降低(P＜0.05),IL-2、IFN-γ水平较治疗前显著升高(P＜0.05).胸腔循环热灌注化疗治疗恶性胸腔积液安全有效,有助提高机体细胞免疫功能.
채용흉강순배열관주화료방법치료55례악성흉강적액환자,완전완해23례(41.8％),국부완해25례(45.5％),은정4례(7.3％),진전3례(5.5％),유효솔87.3％.치료후흉강적액IL-10、IL-6수평교치료전현저강저(P＜0.05),IL-2、IFN-γ수평교치료전현저승고(P＜0.05).흉강순배열관주화료치료악성흉강적액안전유효,유조제고궤체세포면역공능.
Malignant pleural effusion is a common complication of advanced cancer.The present study employed chest circulating hot infusion chemotherapy for 55 cases of malignant pleural effusion.The outcomes were complete remission (n =23,41.8％),partial remission (n =25,45.5％),stable disease (n=4,7.3 ％) and progressive disease (n =3,5.5％).And the effective rate was 87.3％.After treatment,the levels of interleukin-10 (IL-10) and interleukin-6 (IL-6) were significantly lower than those before treatment (P ＜ 0.05).And the levels of interleukin-2 (IL-2) and interferon-gamma (IFN-γ) were significantly higher than those before treatment (P ＜ 0.05).Pleural circulation perfusion chemotherapy is both safe and effective in the treatment of malignant pleural effusion.And it helps to enhance immune functions and improve the quality-of-life of patients.