CAJ | 학술논문

采用回顾性方法分析系统性红斑狼疮(SLE)血液系统损害的特征,将445例确诊的SLE患者根据血液学异常分为WBC减少组、PLT减少组、贫血组及全血细胞减少组,血液学正常的SLE患者为对照组.血液学正常94例(21.1％),血液学异常351例(78.9％),其中贫血249例(56.0％),白细胞减少123例(27.6％),血小板减少60例(13.5％),全血细胞减少38例(8.5％).贫血组患者的肾损害发生率高于对照组(P＜0.01);血液系统损害的SLE患者血C3水平更低(P＜0.05),疾病活动指数(SLEDAI)更高(P＜0.01).贫血是SLE最常见的血液系统损害表现之一,血液系统损害的SLE患者疾病活动明显,其血C3水平更低,SLEDAI评分更高.
채용회고성방법분석계통성홍반랑창(SLE)혈액계통손해적특정,장445례학진적SLE환자근거혈액학이상분위WBC감소조、PLT감소조、빈혈조급전혈세포감소조,혈액학정상적SLE환자위대조조.혈액학정상94례(21.1％),혈액학이상351례(78.9％),기중빈혈249례(56.0％),백세포감소123례(27.6％),혈소판감소60례(13.5％),전혈세포감소38례(8.5％).빈혈조환자적신손해발생솔고우대조조(P＜0.01);혈액계통손해적SLE환자혈C3수평경저(P＜0.05),질병활동지수(SLEDAI)경고(P＜0.01).빈혈시SLE최상견적혈액계통손해표현지일,혈액계통손해적SLE환자질병활동명현,기혈C3수평경저,SLEDAI평분경고.
To explore the characteristics of hematological abnormalities in patients with systemic lupus erythematosus (SLE) through retrospective analysis.A total of 445 SLE patients were recruited and divided into 5 groups of low white blood cell,immune thrombopenic purpura,anemia,pancytopenia and control without hematological abnormalities.Among them,351 (78.9％) had hematological abnormalities and 94 (21.1％) without hematological abnormities.The prevalence of anemia,leucocytopenia,thrombocytopenia and pancytopenia were 56.0％ (246/445),27.6％ (123/445),13.5％ (60/445) and 8.5％ (38/445) respectively.The incidence of renal damage in anemia group was significantly higher than that in control group (P ＜ 0.01).SLE patients with hematological abnormalities had lower complement C3 levels (P ＜ 0.05) and higher systemic lupus erythematosus disease activity index (SLEDAI) (P ＜ 0.01).Anemia is the most common findings in SLE patients with hematological abnormalities who have lower complement C3 levels and higher SLEDAI.