CAJ | 학술논문

将218例接受含奥沙利铂治疗方案的患者随机分为试验组(120例)和对照组(98例).试验组在化疗期间给予硫辛酸联合钠钾镁钙葡萄糖注射液静脉滴注;对照组仅单纯给予生理盐水500 ml静脉滴注.两组在化疗4、8、12个周期时急性神经毒性的发生率和4、8个周期后累积性神经毒性发生率差异均无统计学意义(P＞0.05).12个周期后,试验组共有31例患者出现神经毒性,其中2、3、4级发生例数分别为5(4.2％)、8(6.7％)、0例,对照组56例患者出现神经毒性,其中2、3、4级发生例数分别为13(13.3％)、21(21.4％)、5(5.1％),2、3、4级神经毒性组间差异均具有统计学意义(P＜0.05).
장218례접수함오사리박치료방안적환자수궤분위시험조(120례)화대조조(98례).시험조재화료기간급여류신산연합납갑미개포도당주사액정맥적주;대조조부단순급여생리염수500 ml정맥적주.량조재화료4、8、12개주기시급성신경독성적발생솔화4、8개주기후루적성신경독성발생솔차이균무통계학의의(P＞0.05).12개주기후,시험조공유31례환자출현신경독성,기중2、3、4급발생례수분별위5(4.2％)、8(6.7％)、0례,대조조56례환자출현신경독성,기중2、3、4급발생례수분별위13(13.3％)、21(21.4％)、5(5.1％),2、3、4급신경독성조간차이균구유통계학의의(P＜0.05).
A total of 218 patients on chemotherapeutic regimens containing oxaliplatin were randomly divided into experimental (n =120) and control (n =98) groups.The experimental group received an intravenous infusion of lipoic acid plus sodium potassium magnesium calcium and glucose injection.The control group had only normal saline.Overall incidence of neurotoxicity and toxicity grade of peripheral nerve were observed after 4,8 and 12 cycles.Those with neurotoxic symptoms were followed up for 1 year.No significantly statistical difference existed in the incidence of peripheral neurotoxicity after 4,8 cycles (P ＞0.05).After 12 cycles,31 patients in the experimental group had an onset of neurotoxicity of grade3 (n=8,6.7％) &grade4 (n=0) versus21 cases of grade3 (n=21,21.4％) and grade4 (n=5,5.1％) in the control group.Statistically significant differences existed between grades 3 and 4 neurotoxicity (P ＜0.05).After 1 year of follow-up,the incidence of grade 1 of neurotoxicity was 2.5％ (n =3) in the experimental group versus 23.7％ (n =9) in the control group.And the inter-group difference was statistically significant (P ＜ 0.05).Lipoic acid plus sodium potassium magnesium,calcium and glucose injection can effectively prevent the occurrences of acute and chronic peripheral neurotoxicity associated with oxaliplatin.