CAJ | 학술논문

将107例患者用计算机随机分为3组,A组34例采用卡介菌多糖核酸针皮损内注射,B组36例采用复发甘草酸苷片口服,C组37例采用卡介菌多糖核酸针皮损内注射联合复发甘草酸苷片口服.各组于治疗前及治疗后3个月时检测患者细胞免疫功能.另设正常对照组30例.3组治疗前后自身配对比较,CD4+、CD4+/CD8+比值升高(均P＜0.05),CD8+降低(均P＜0.05).治疗后C组与A、B组比较,CD4+升高(均P＜0.05),CD8+降低(均P＜0.05).C组有效率91.9％,高于其他两组(均P＜0.05).说明卡介菌多糖核酸针皮损内注射联合复发甘草酸苷片可提高白癜风患者的细胞免疫功能和治疗有效率.
장107례환자용계산궤수궤분위3조,A조34례채용잡개균다당핵산침피손내주사,B조36례채용복발감초산감편구복,C조37례채용잡개균다당핵산침피손내주사연합복발감초산감편구복.각조우치료전급치료후3개월시검측환자세포면역공능.령설정상대조조30례.3조치료전후자신배대비교,CD4+、CD4+/CD8+비치승고(균P＜0.05),CD8+강저(균P＜0.05).치료후C조여A、B조비교,CD4+승고(균P＜0.05),CD8+강저(균P＜0.05).C조유효솔91.9％,고우기타량조(균P＜0.05).설명잡개균다당핵산침피손내주사연합복발감초산감편가제고백전풍환자적세포면역공능화치료유효솔.
A total of 107 vitiligo patients were randomly divided into 3 groups.Group A received an intralesional injection of Bacillus Calmette-Guérin-polysaccharide nucleic acid (BCG-PSN) (n =34),group B Compound Glycyrrhizin Tablets (n =36) and group C both (n =37).Before treatment and 3 months after treatment,cellular immune function was detected for each group.Paired comparisons of 3 groups before and after treatment showed that CD4 +,CD4 +/CD8 + ratio increased (all P ＜ 0.05) and CD8 + decreased (P ＜0.05).After treatment,as compared with groups A and B,CD4 + increases (both P ＜ 0.05) and CD8 + decreased in group C (P ＜0.05).Group C had an efficiency rate of 91.9％ and it was higher than the other two groups (both P ＜ 0.05).An intralesional injection of BCG-PSN plus Compound Glycyrrhizin Tablets could improve immune function and treat vitiligo patients efficiently.