CAJ | 학술논문

收集2008年1月-2013年3月在北京协和医院住院且出院诊断为原发性干燥综合征(PSS)的749例患者的病历资料.比较其中PSS合并肺动脉高压患者(PSS-PH组)与未合并肺动脉高压者(PSS-non PH组)的临床表现、实验室检查特征和预后.结果显示,PSS-PH组与PSS-non PH组相比:雷诺现象(36.8％比20.0％,P=0.05)、心包积液(55.3％比0.0％,P＜0.01)、白细胞减低(42.1％比30.0％,P=0.03)、IgG水平[(28.8±11.2)g/L比(21.5±10.0)g/L,P=0.01]、甲状腺功能减低比例(34.2％比12.5％,P=0.05)均有统计学差异.提示PSS患者出现白细胞减低、甲状腺功能低下、IgG升高和心包积液者容易合并肺动脉高压.
수집2008년1월-2013년3월재북경협화의원주원차출원진단위원발성간조종합정(PSS)적749례환자적병력자료.비교기중PSS합병폐동맥고압환자(PSS-PH조)여미합병폐동맥고압자(PSS-non PH조)적림상표현、실험실검사특정화예후.결과현시,PSS-PH조여PSS-non PH조상비:뢰낙현상(36.8％비20.0％,P=0.05)、심포적액(55.3％비0.0％,P＜0.01)、백세포감저(42.1％비30.0％,P=0.03)、IgG수평[(28.8±11.2)g/L비(21.5±10.0)g/L,P=0.01]、갑상선공능감저비례(34.2％비12.5％,P=0.05)균유통계학차이.제시PSS환자출현백세포감저、갑상선공능저하、IgG승고화심포적액자용역합병폐동맥고압.
The clinical data were collected from medical record of 749 patients admitted into Peking Union Medical College Hospital from January 2008 to March 2013.They were diagnosed with primary Sj(o)gren's syndrome (PSS) at discharge.Clinical manifestations,laboratory results and outcomes were compared between PSS patients with pulmonary hypertension (PSS-PH) and those without (PSS-non PH).PSS-PH group had higher proportions of Renault phenomenon (36.8％ vs.20.0％,P =0.05),pericardial effusion (55.3％ vs.0.0％,P＜0.01),leukocytopenia (42.1％ vs.30.0％,P =0.03),elevated IgG level [(28.8 ±11.2) vs.(21.5 ±10.0) g/L,P=0.01] and hypothyroidism(34.2％ vs.12.5％,P=0.05) with significant significance.The PSS patients had leukocytopenia low thyroid function,rising IgG and pericardial effusion with pulmonary hypertension.