CAJ | 학술논문

收集我院脂代谢紊乱的痰浊遏阻型患者101例,分为3组,A组30例,单用降脂方(JZF);B组39例,单用阿托伐他汀钙(ATV);C组32例,JZF联合ATV治疗.观察治疗2周前后患者的血脂水平、肝肾功能、中医证候积分、治疗有效率.总有效率C组明显优于B组(90.62％与76.92％,u=1.97,P＜0.05);中医证候积分改善C组显著优于A、B两组(C对A为90.62％与80.00％,u=1.98,P＜0.05;C对B为90.62％与51.28％,u=4.11,P＜0.01);TC和LDL-C的改善C组显著优于另两组(CTC和CLDL-C对A组,P＜0.01;CTC和CLDL-C对B组,P＜0.01);疗程中未发现患者肝肾功能异常.提示ATV和JZF联用可能存在一定的协同降脂作用,JZF和ATV单用短期内无明显疗效差异.
수집아원지대사문란적담탁알조형환자101례,분위3조,A조30례,단용강지방(JZF);B조39례,단용아탁벌타정개(ATV);C조32례,JZF연합ATV치료.관찰치료2주전후환자적혈지수평、간신공능、중의증후적분、치료유효솔.총유효솔C조명현우우B조(90.62％여76.92％,u=1.97,P＜0.05);중의증후적분개선C조현저우우A、B량조(C대A위90.62％여80.00％,u=1.98,P＜0.05;C대B위90.62％여51.28％,u=4.11,P＜0.01);TC화LDL-C적개선C조현저우우령량조(CTC화CLDL-C대A조,P＜0.01;CTC화CLDL-C대B조,P＜0.01);료정중미발현환자간신공능이상.제시ATV화JZF련용가능존재일정적협동강지작용,JZF화ATV단용단기내무명현료효차이.
A total of 101 lipid metabolism disorder patients with traditional Chinese medicine (TCM) syndrome of phlegm and turbidity retardation were collected and randomly divided into group A:Jiangzhi Decoction (JZF) alone (n =30),group B:atorvastatin (ATV) alone (n =39) and group C:JZF plus ATV (n =32).Lipid level,liver and kidney function,total effective rate and TCM scores were observed after a course of 2 weeks.Total effective rate:Group C was significantly superior to group B (90.62％ vs.76.92％,u =1.97,P ＜ 0.05) ; TCM score:Group C had a statistically superior advantage over groups A andB (C vs.A,90.62％ vs.80.00％,u=1.98,P＜0.05; Cvs.B,90.62％ vs.51.28％,u=4.11,P ＜0.01); TC and Improvements of total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C):Group C demonstrated marked decreases in both TC and LDL (CTC & CLDL-C vs.group A,P ＜ 0.01 ; CTC & CLDL-C vs.group B,P ＜ 0.01),no abnormal liver or kidney function occurred during the follow-up period.Thus JZF and ATV may have synergic lipid-lowering effects.And single uses of JZF and ATV have no marked differences in short term efficacy.