中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2012年
10期
706-710
,共5页
林彬%钱若兵%傅先明%韩晓鹏%张浩%胡文富%伊涛%魏祥品%牛朝诗%汪业汉
林彬%錢若兵%傅先明%韓曉鵬%張浩%鬍文富%伊濤%魏祥品%牛朝詩%汪業漢
림빈%전약병%부선명%한효붕%장호%호문부%이도%위상품%우조시%왕업한
海洛因依赖%诱发电位%冲动行为%神经心理学测验
海洛因依賴%誘髮電位%遲動行為%神經心理學測驗
해락인의뢰%유발전위%충동행위%신경심이학측험
Heroin dependence%Evoked potentials%Impulsive behavior%Neuropsychological tests
目的 探讨海洛因成瘾者错误加工过程中错误相关负波(ERN)与冲动行为的相关性.方法 运用神经心理学试验范式,海洛因成瘾组(HA组,20例)和健康对照组(HC组,20名)在执行爱荷华赌博任务(IGT)时进行事件相关电位描记,分析比较两组被试ERN的波幅和潜伏期,并与冲动性量表(BIS)-11的测评结果作相关分析.结果 HA组决策进程对净分数无影响,其BIS评分、选择“高频损失”纸牌次数[(75.2±7.6)分；(105.5 ±22.2)次]高于HC组[(64.3±8.4)分；(73.8±16.4)次],差异有统计学意义(t=-5.39,-9.24；均P＜0.05).两组被试IGT中错误反馈后均出现明显的ERN波形,HA组ERN的波幅[(4.23 ±0.87) μV]低于HC组[(6.11 ±1.09) μV],差异有统计学意义(=5.96,P＜0.05),而两组潜伏期差异无统计学意义[HC组:(102.1±28.2) ms,HA组:(107.8 ±24.2) ms；t=-0.62,P=0.54]；两组被试ERN波幅均与各自BIS评分呈负相关(HC组:r=-0.66,HA组:r=-0.78,均P＜0.05).结论 海洛因成瘾者错误加工能力下降,可能是产生及维持成瘾行为的原因之一,ERN可作为预测成瘾者冲动行为及错误加工能力的指标.
目的 探討海洛因成癮者錯誤加工過程中錯誤相關負波(ERN)與遲動行為的相關性.方法 運用神經心理學試驗範式,海洛因成癮組(HA組,20例)和健康對照組(HC組,20名)在執行愛荷華賭博任務(IGT)時進行事件相關電位描記,分析比較兩組被試ERN的波幅和潛伏期,併與遲動性量錶(BIS)-11的測評結果作相關分析.結果 HA組決策進程對淨分數無影響,其BIS評分、選擇“高頻損失”紙牌次數[(75.2±7.6)分；(105.5 ±22.2)次]高于HC組[(64.3±8.4)分；(73.8±16.4)次],差異有統計學意義(t=-5.39,-9.24；均P＜0.05).兩組被試IGT中錯誤反饋後均齣現明顯的ERN波形,HA組ERN的波幅[(4.23 ±0.87) μV]低于HC組[(6.11 ±1.09) μV],差異有統計學意義(=5.96,P＜0.05),而兩組潛伏期差異無統計學意義[HC組:(102.1±28.2) ms,HA組:(107.8 ±24.2) ms；t=-0.62,P=0.54]；兩組被試ERN波幅均與各自BIS評分呈負相關(HC組:r=-0.66,HA組:r=-0.78,均P＜0.05).結論 海洛因成癮者錯誤加工能力下降,可能是產生及維持成癮行為的原因之一,ERN可作為預測成癮者遲動行為及錯誤加工能力的指標.
목적 탐토해락인성은자착오가공과정중착오상관부파(ERN)여충동행위적상관성.방법 운용신경심이학시험범식,해락인성은조(HA조,20례)화건강대조조(HC조,20명)재집행애하화도박임무(IGT)시진행사건상관전위묘기,분석비교량조피시ERN적파폭화잠복기,병여충동성량표(BIS)-11적측평결과작상관분석.결과 HA조결책진정대정분수무영향,기BIS평분、선택“고빈손실”지패차수[(75.2±7.6)분；(105.5 ±22.2)차]고우HC조[(64.3±8.4)분；(73.8±16.4)차],차이유통계학의의(t=-5.39,-9.24；균P＜0.05).량조피시IGT중착오반궤후균출현명현적ERN파형,HA조ERN적파폭[(4.23 ±0.87) μV]저우HC조[(6.11 ±1.09) μV],차이유통계학의의(=5.96,P＜0.05),이량조잠복기차이무통계학의의[HC조:(102.1±28.2) ms,HA조:(107.8 ±24.2) ms；t=-0.62,P=0.54]；량조피시ERN파폭균여각자BIS평분정부상관(HC조:r=-0.66,HA조:r=-0.78,균P＜0.05).결론 해락인성은자착오가공능력하강,가능시산생급유지성은행위적원인지일,ERN가작위예측성은자충동행위급착오가공능력적지표.
Objective To investigate the relationship between impulsive behaviors and the errorrelated negativity (ERN) component of event-related potentials of error processing in heroin addicts.Methods Using the paradigms for psychological experiment,the Iowa gambling task (IGT) was performed both in heroin addiction group (HA group,20 cases) and healthy control group (HC group,20 cases),and the inspection of electroencephalography was underwent in all subjects concurrently.Following the collection of data,the amplitude and latency of ERN were compared between the two groups,and then the relationship between the amplitude of ERN and the scores of Barratt Impulsiveness Scale (BIS-11) was analyzed separately.Results Decision-making course had no effect on the net score remarkably in HA group (F =1.21,P ＞0.05).Compared with HC group(64.3 ±8.4,73.8 ± 16.4),BIS score as well as the numbers of high frequency loss cards were significantly higher in HA group(75.2 ±7.6,105.5 ±22.2; t =-5.39,-9.24 ; P ＜ 0.05),while both the two groups had visible waveforms of ERN,and the amplitude was markedly lower in HA group(HA:(4.23 ±0.87) μV,HC:(6.11 ± 1.09) μV; t =5.96,P ＜0.05),but no statistical difference was found in latency of these two groups(HC:(102.1 ±28.2) ms,HA:(107.8 ±24.2) ms;t =-0.62,P =0.54),and the amplitude of the two groups was negatively associated with BIS score respectively in both two groups (HC:r =-0.66,HA:r =-0.78 ; both P ＜ 0.05).Conclusion The reduced capability of error processing maybe partly contribute to both addiction and relapse to heroin addict,and the ERN event-related potential could be regarded as an indicator of impulsive behaviors and the capability error processing.
