CAJ | 학술논문

目的描述伴幻影失神发作的成人特发性全面性癫痫6例患者的临床表现及脑电图特点.方法 6例患者均于2007年4月至2011年12月就诊于我院门诊,对所有患者的临床表现、家族史、既往史、治疗情况进行详细记录,并进行多次长程或视频脑电图检查并配合计数试验检查.结果 6例患者均具有相似的临床表现和脑电图特点,具体表现为:(1)意识障碍、轻微的失神发作,失神发作时脑电图表现为3.0～3.5 Hz的全面性尖(棘)慢波发放(GSWD)；(2)强直阵挛发作,且多继发于失神持续状态；(3)频繁出现的失神持续状态；(4)觉醒期脑电图表现为频繁的片段化、短暂或长时间的GSWD出现,而睡眠期仅见片段化GSWD出现.所有患者均无肌阵挛及其他发作类型出现,均无光敏性.结论伴幻影失神发作的成人特发性全面性癫痫具有特征性的临床表现和脑电图特点,可能属于一种新的癫痫综合征.
목적 묘술반환영실신발작적성인특발성전면성전간6례환자적림상표현급뇌전도특점.방법 6례환자균우2007년4월지2011년12월취진우아원문진,대소유환자적림상표현、가족사、기왕사、치료정황진행상세기록,병진행다차장정혹시빈뇌전도검사병배합계수시험검사.결과 6례환자균구유상사적림상표현화뇌전도특점,구체표현위:(1)의식장애、경미적실신발작,실신발작시뇌전도표현위3.0～3.5 Hz적전면성첨(극)만파발방(GSWD)；(2)강직진련발작,차다계발우실신지속상태；(3)빈번출현적실신지속상태；(4)각성기뇌전도표현위빈번적편단화、단잠혹장시간적GSWD출현,이수면기부견편단화GSWD출현.소유환자균무기진련급기타발작류형출현,균무광민성.결론 반환영실신발작적성인특발성전면성전간구유특정성적림상표현화뇌전도특점,가능속우일충신적전간종합정.
Objective To investigate the clinical and electroencephalogram (EEG) features of patients with idiopathic generalized epilepsy in adults with phantom absences.Methods Six patients were referred to the clinic of epilepsy from April,2007 to December,2011.They all had clinical assessment,EEG,or video EEG confirming absences seizure.Results Six patients showed the following similar clinical-EEG features:(1) mild ictal impairment of consciousness associated with generalized 3.0-3.5 Hz spike and slow wave discharges; (2) late-onset generalized tonic-clonic seizures; (3) absence status epilepticus with or without secondary generalized tonic-clonic seizures; (4) generalized discharges were mostly seen in three types in the awaking stage:fragmented discharge (＜4 s),brief discharge (4-10s) and long-time discharge (＞ 10 s).None of the patients had myoclonic jerks or photosensitivity.One patient' s mother had a history of generalized tonic clonic seizures.One patient had a history of children absence epilepsy and one patient had a history of febrile convulsion in the age of 1-3.Conclusion Idiopathic generalized epilepsy with phantom absences has distinct clinical and EEG features and may become a new idiopathic generalized epilepsy syndrome in adults.