中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2013年
7期
461-464
,共4页
金丽日%柳青%任海涛%关鸿志%郑建彪%崔瑞雪%吴立文%杨荫昌%崔丽英
金麗日%柳青%任海濤%關鴻誌%鄭建彪%崔瑞雪%吳立文%楊蔭昌%崔麗英
금려일%류청%임해도%관홍지%정건표%최서설%오립문%양음창%최려영
边缘叶脑炎%蛋白质类%自身抗体%张力障碍%免疫疗法
邊緣葉腦炎%蛋白質類%自身抗體%張力障礙%免疫療法
변연협뇌염%단백질류%자신항체%장력장애%면역요법
Limbic encephalitis%Proteins%Autoantibodies%Dystonic disorders%Immunotherapy
目的 探讨富亮氨酸胶质瘤失活1蛋白(LGi1)抗体阳性边缘系统脑炎临床特点、诊断及免疫治疗反应,以期引起临床重视.方法 报道国内首例LGi1抗体阳性边缘系统脑炎患者的诊治经过,结合临床表现、结构及功能影像学、脑电图、免疫治疗反应以及相关文献,分析该疾病的特点.结果 患者为老年男性,表现为亚急性起病的近期记忆功能减退,抗癫痫药物抵抗的频繁、短暂的面-臂肌张力障碍发作,顽固性低钠血症,影像学提示颞叶内侧区受累.血和脑脊液LGi1抗体阳性.经静脉丙种球蛋白治疗,临床痊愈.结论 LGi1抗体阳性边缘系统脑炎有独特的临床表现和较好的免疫治疗效果,及早诊治可明显改善预后.
目的 探討富亮氨痠膠質瘤失活1蛋白(LGi1)抗體暘性邊緣繫統腦炎臨床特點、診斷及免疫治療反應,以期引起臨床重視.方法 報道國內首例LGi1抗體暘性邊緣繫統腦炎患者的診治經過,結閤臨床錶現、結構及功能影像學、腦電圖、免疫治療反應以及相關文獻,分析該疾病的特點.結果 患者為老年男性,錶現為亞急性起病的近期記憶功能減退,抗癲癇藥物牴抗的頻繁、短暫的麵-臂肌張力障礙髮作,頑固性低鈉血癥,影像學提示顳葉內側區受纍.血和腦脊液LGi1抗體暘性.經靜脈丙種毬蛋白治療,臨床痊愈.結論 LGi1抗體暘性邊緣繫統腦炎有獨特的臨床錶現和較好的免疫治療效果,及早診治可明顯改善預後.
목적 탐토부량안산효질류실활1단백(LGi1)항체양성변연계통뇌염림상특점、진단급면역치료반응,이기인기림상중시.방법 보도국내수례LGi1항체양성변연계통뇌염환자적진치경과,결합림상표현、결구급공능영상학、뇌전도、면역치료반응이급상관문헌,분석해질병적특점.결과 환자위노년남성,표현위아급성기병적근기기억공능감퇴,항전간약물저항적빈번、단잠적면-비기장력장애발작,완고성저납혈증,영상학제시섭협내측구수루.혈화뇌척액LGi1항체양성.경정맥병충구단백치료,림상전유.결론 LGi1항체양성변연계통뇌염유독특적림상표현화교호적면역치료효과,급조진치가명현개선예후.
Objective To study the clinical features,diagnosis and immunotherapy response of leucine-rich glioma inactivated-1 (LGi1)-antibody positive limbic encephalitis (LE).Methods A case of anti-LGi1 LE in a 68-year-old male was reported.The related literature was reviewed and clinical features were summarized.Results Anti-LGi1 LE is characterized by subacute development of amnesia,frequent,brief,and drug-resistant faciobrachial dystonic seizures,refractory hyponatremia,mesial temporal lobe abnormalities on magnetic resonance imaging and positron emission tomography,and a good response to intravenous immunoglobulin therapy.Conclusion Early recognition and appropriate immunotherapy for patients with LE associated with anti-LGi1 antibody may prevent irreversible injury to limbic function.
