中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2013年
10期
687-691
,共5页
阿尔茨海默病%认知障碍%脑电描记术
阿爾茨海默病%認知障礙%腦電描記術
아이자해묵병%인지장애%뇌전묘기술
Alzheimer disease%Cognition disorders%Electroencephalography
目的 探讨阿尔茨海默病(Alzheimer's disease,AD)、轻度认知功能障碍(mildcognitive impairment,MCI)和健康老年人的脑电复杂度(Lemple-Zie complexity,LZC)特点,以及LZC值在鉴别AD、MCI以及健康老年人中的应用价值.方法 对30例AD患者、30例MCI患者及20名健康老年对照者进行安静闭目状态下的脑电监测,用Matlab自编软件计算各组不同导联及脑区的LZC值.结果 (1) AD组、MCI组、对照组全部导联平均值依次是0.396±0.036、0.470±0.051、0.523±0.055,AD组和MCI组与对照组相比均有所降低,差别有统计学意义(F=43.092,P=0.000).(2)AD组的LZC值在各导联处[(0.373±0.042) ～(0.430±0.083)]、全部导联均值、左右半球、双侧额颞区的均明显低于对照组[(0.498±0.067) ～(0.566±0.059)],差异有统计学意义(=3.602 ～ 8.747,P=0.000 ～0.010)；且在双侧前中颞、双侧额区、左顶区具有较大降幅,均大于23％.(3)除导联T6外,AD组的LZC值在各导联处[(0.373±0.042) ～ (0.418±0.063)]、全部导联均值、左右半球及双侧额颞区均低于MCI组[(0.455±0.072) ～ (0.489±0.063)],差异有统计学意义(在T5导联处,t =2.038、P=0.041,其余t=4.178 ～7.424,均P=0.000).(4) MCI组的LZC值在全部导联均值、左右半球、双侧颞区、左额、双侧顶区较对照组降低,差异有统计学意义.结论 随着认知功能的降低,脑电信号复杂度值可出现同向改变,说明LZC值可在一定程度上反映大脑认知功能的变化；出现额、颞区复杂度异常的MCI患者与AD的发生存在一定程度的联系.
目的 探討阿爾茨海默病(Alzheimer's disease,AD)、輕度認知功能障礙(mildcognitive impairment,MCI)和健康老年人的腦電複雜度(Lemple-Zie complexity,LZC)特點,以及LZC值在鑒彆AD、MCI以及健康老年人中的應用價值.方法 對30例AD患者、30例MCI患者及20名健康老年對照者進行安靜閉目狀態下的腦電鑑測,用Matlab自編軟件計算各組不同導聯及腦區的LZC值.結果 (1) AD組、MCI組、對照組全部導聯平均值依次是0.396±0.036、0.470±0.051、0.523±0.055,AD組和MCI組與對照組相比均有所降低,差彆有統計學意義(F=43.092,P=0.000).(2)AD組的LZC值在各導聯處[(0.373±0.042) ～(0.430±0.083)]、全部導聯均值、左右半毬、雙側額顳區的均明顯低于對照組[(0.498±0.067) ～(0.566±0.059)],差異有統計學意義(=3.602 ～ 8.747,P=0.000 ～0.010)；且在雙側前中顳、雙側額區、左頂區具有較大降幅,均大于23％.(3)除導聯T6外,AD組的LZC值在各導聯處[(0.373±0.042) ～ (0.418±0.063)]、全部導聯均值、左右半毬及雙側額顳區均低于MCI組[(0.455±0.072) ～ (0.489±0.063)],差異有統計學意義(在T5導聯處,t =2.038、P=0.041,其餘t=4.178 ～7.424,均P=0.000).(4) MCI組的LZC值在全部導聯均值、左右半毬、雙側顳區、左額、雙側頂區較對照組降低,差異有統計學意義.結論 隨著認知功能的降低,腦電信號複雜度值可齣現同嚮改變,說明LZC值可在一定程度上反映大腦認知功能的變化；齣現額、顳區複雜度異常的MCI患者與AD的髮生存在一定程度的聯繫.
목적 탐토아이자해묵병(Alzheimer's disease,AD)、경도인지공능장애(mildcognitive impairment,MCI)화건강노년인적뇌전복잡도(Lemple-Zie complexity,LZC)특점,이급LZC치재감별AD、MCI이급건강노년인중적응용개치.방법 대30례AD환자、30례MCI환자급20명건강노년대조자진행안정폐목상태하적뇌전감측,용Matlab자편연건계산각조불동도련급뇌구적LZC치.결과 (1) AD조、MCI조、대조조전부도련평균치의차시0.396±0.036、0.470±0.051、0.523±0.055,AD조화MCI조여대조조상비균유소강저,차별유통계학의의(F=43.092,P=0.000).(2)AD조적LZC치재각도련처[(0.373±0.042) ～(0.430±0.083)]、전부도련균치、좌우반구、쌍측액섭구적균명현저우대조조[(0.498±0.067) ～(0.566±0.059)],차이유통계학의의(=3.602 ～ 8.747,P=0.000 ～0.010)；차재쌍측전중섭、쌍측액구、좌정구구유교대강폭,균대우23％.(3)제도련T6외,AD조적LZC치재각도련처[(0.373±0.042) ～ (0.418±0.063)]、전부도련균치、좌우반구급쌍측액섭구균저우MCI조[(0.455±0.072) ～ (0.489±0.063)],차이유통계학의의(재T5도련처,t =2.038、P=0.041,기여t=4.178 ～7.424,균P=0.000).(4) MCI조적LZC치재전부도련균치、좌우반구、쌍측섭구、좌액、쌍측정구교대조조강저,차이유통계학의의.결론 수착인지공능적강저,뇌전신호복잡도치가출현동향개변,설명LZC치가재일정정도상반영대뇌인지공능적변화；출현액、섭구복잡도이상적MCI환자여AD적발생존재일정정도적련계.
Objective To investigate the Lemple-Zie complexity (LZC) characteristics in patients with Alzheimer' s disease(AD),mild cognitive impairment(MCI) and normal elderly,and the possibility of differentiating AD,MCI and normal elderly by LZC.Methods Electroencephalogram (EEG) of 30 AD patients,30 MCI patients and 20 normal elderly with eyes closed in rest state were recorded.In acquired EEG data,2048 points(10.14 s)of each channel were selected for LZC calculation by Matlab 7.0 software.Results (1) The average LZC values in AD,MCI and control groups were 0.396 ± 0.036,0.470 ±0.051,0.523 ±0.055 respectively.As compared with control group,the values in AD and MCI groups were decreased (F =43.092,P =0.000).(2) LZC values of AD in all channels (from 0.373 ± 0.042 to 0.430 ±0.083),whole brain,bilateral hemispheres,frontal and temporal areas were significantly lower than those in the normal group (from 0.498 ± 0.067 to 0.566 ± 0.059 ; t =3.602-8.747,P =0.000-0.010),and showed the significant decline(＞ 23％)in bilateral anterior middle temporal,frontal areas,the left parietal area.(3) Except the T6 channel,LZC values of AD groups in the remaining channels(from 0.373 ±0.042 to 0.418±0.063),the whole brain,bilateral hemispheres,frontal and temporal areas were significantly lower than those in the MCI group(from 0.455 ± 0.072 to 0.489 ± 0.063 ; in T5 channel,t =2.038,P =0.041,the others t=4.178-7.424,all P=0.000).(4) LZC values of MCI groups in the whole brain,bilateral hemispheres,temporal areas,parietal areas,the left frontal area were notably lower than those in the control group.Conclusions With the decline of the cognitive function,the EEG complexity value shows the parallel change.It suggests that the EEG complexity value can reflect the change of brain function in the duration from normal age to dementia in some degree; The MCI patients with abnormal LZC values in temporal and frontal lobes have a certain degree relation with the occurrence of AD.
