CAJ | 학술논문

目的探讨不同缺血程度脑组织在0.1～2.0THz波段的时域光谱特征.方法采用线栓法制备大鼠大脑中动脉闭塞模型,利用透射式太赫兹时域光谱(THz-TDS)测量缺血3、6、12、24h脑组织的太赫兹时域光谱,分析吸收系数曲线中出现的峰-谷吸收系数差值(PVD).结果不同程度缺血脑组织太赫兹波吸收系数曲线与正常脑组织存在明显差异;在1.4、1.5、1.6、1.7、1.8、1.9THz频率处PVD值的减少程度与脑组织缺血严重程度正相关(P＜0.05);太赫兹所检测的缺血区域细胞密度明显降低,脑含水量明显升高.结论太赫兹时域光谱可于缺血早期(3h内)检测出脑组织缺血,具有较好的应用前景.
목적 탐토불동결혈정도뇌조직재0.1～2.0THz파단적시역광보특정.방법 채용선전법제비대서대뇌중동맥폐새모형,이용투사식태혁자시역광보(THz-TDS)측량결혈3、6、12、24h뇌조직적태혁자시역광보,분석흡수계수곡선중출현적봉-곡흡수계수차치(PVD).결과 불동정도결혈뇌조직태혁자파흡수계수곡선여정상뇌조직존재명현차이;재1.4、1.5、1.6、1.7、1.8、1.9THz빈솔처PVD치적감소정도여뇌조직결혈엄중정도정상관(P＜0.05);태혁자소검측적결혈구역세포밀도명현강저,뇌함수량명현승고.결론 태혁자시역광보가우결혈조기(3h내)검측출뇌조직결혈,구유교호적응용전경.
Objective To explore Terahertz time-domain spectra of ischemic brain tissue in different time on rats.Methods The model of middle cerebral artery occlusion (MACO) was established and transmissive Terahertz time-domain spectroscopy of the brain tissue of occlusive lesions was measured.The Peaks-Valley difference (PVD) in absorption coefficient curve was analyzed.Results The ischemia brain tissues in 3,6,12 and 24 hours had significant differences with normal brain tissue.The PVD value was decreased significantly in 1.4,1.5,1.6,1.7,1.8,1.9 THz frequencies(P ＜ 0.05).The cell density of ischemic brain tissue was significantly reduced and the brain water content was significantly higher.Conclusions erahertz time-domain spectroscopy could detect ischemia within 3 hours after artery occlusion.PVD value is positively related to the severity of brain tissue ischemia.