CAJ | 학술논문

目的探讨急性颅脑损伤后,患者血清性激素动态变化对其损伤程度及预后的影响.方法根据格拉斯哥昏迷评分(GCS)对患者损伤程度进行(轻、中、重)分型,采用格拉斯哥预后评分(GOS)对患者预后进行评定,采集急性颅脑损伤后轻型、中型、重型共153例患者伤后第1天、第7天静脉血,使用雌二醇(E2)、孕酮(P)、睾酮(T)性激素定量测定的方法,动态监测306份血清中三种性激素的含量,分析急性颅脑损伤患者血清E2、P、T动态变化与其损伤程度及预后的相关关系.结果急性颅脑损伤轻、中、重型患者第1天血清E2、P、T含量较第7天明显升高,且GCS评分与E2、P、T含量呈负相关关系,患者血清E2、P、T含量与患者GOS评分也呈负相关,P＜0.05.结论早期动态监测急性颅脑损伤患者血清E2、P、T含量变化,可作为尽早、快速判断患者损伤程度及预后的指标,并为必要时对急性颅脑损伤患者进行干预治疗(适当补充性激素)提供治疗依据.
목적 탐토급성로뇌손상후,환자혈청성격소동태변화대기손상정도급예후적영향.방법 근거격랍사가혼미평분(GCS)대환자손상정도진행(경、중、중)분형,채용격랍사가예후평분(GOS)대환자예후진행평정,채집급성로뇌손상후경형、중형、중형공153례환자상후제1천、제7천정맥혈,사용자이순(E2)、잉동(P)、고동(T)성격소정량측정적방법,동태감측306빈혈청중삼충성격소적함량,분석급성로뇌손상환자혈청E2、P、T동태변화여기손상정도급예후적상관관계.결과 급성로뇌손상경、중、중형환자제1천혈청E2、P、T함량교제7천명현승고,차GCS평분여E2、P、T함량정부상관관계,환자혈청E2、P、T함량여환자GOS평분야정부상관,P＜0.05.결론 조기동태감측급성로뇌손상환자혈청E2、P、T함량변화,가작위진조、쾌속판단환자손상정도급예후적지표,병위필요시대급성로뇌손상환자진행간예치료(괄당보충성격소)제공치료의거.
Objective To evaluate the effects of the dynamic changes of serum sex hormones on the injury severity and prognosis of acute craniocerebral injury.Methods The injury severity (light,medium,and heavy) was evaluated through GCS score and the prognosis was evaluated with GOS.Intravenous blood was collected respectively from 153 patients with light,medium,and heavy injury at the first day and the 7th day after acute head injury.The quantitative method was used dynamically to determine the sexual hormone contents (serum E2,P,and T) in the serum.The relationships among the dynamic changes of serum sex hormones,the severity of injury and the prognosis after acute craniocerebral injury were analyzed.Results The contents of the serum E2,P,and T at the first day after injury were increased significantly than those at the seventh day in the patients with all types of acute head injury.Meanwhile,the changes showed that the contents of the serum E2,P,and T were increased with the decrease of GCS score at both time points.There was a negative correlation between the contents of serum E2,P,and T and the GCS score and GOS score (P ＜ 0.05).Conclusions Early dynamically monitoring the changes of sexal hormone contents in serum of patients with acute traumatic craniocerebral injury could be used as the early indicators of rapid judgment of injury severity and prognosis.It could provide the basis for intervene therapy (proper application of sex hormones) in patients with acute craniocerebral injury.