中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2014年
8期
831-835
,共5页
石林%杨岸超%王秀%刘焕光%张鑫%张建国
石林%楊岸超%王秀%劉煥光%張鑫%張建國
석림%양안초%왕수%류환광%장흠%장건국
脑深部电刺激%磁共振成像%活体研究%病理改变%热损伤
腦深部電刺激%磁共振成像%活體研究%病理改變%熱損傷
뇌심부전자격%자공진성상%활체연구%병리개변%열손상
Deep brain stimulation%Magnetic resonance imaging%In vivo study%Pathology%Heating injury
目的 通过对比超高场强MRI(7.0T和3.0T)与高场强MRI(1.5 T)下深部脑刺激(DBS)电极周围组织的病理学变化,深入探讨射频磁场中DBS电极热效应对周围组织的影响.方法 雄性新西兰白兔18只,随机分人7.0T组(n=6),3.0T组(n=6)及高场强1.5T组(n=6).各组动物以左侧丘脑腹后核为靶点,植入全套DBS电极和刺激器.术后进行对应场强核磁共振扫描,24 h后对针道周围脑组织进行HE染色及电镜检查,并对组织损伤进行评估.所有统计结果采用均数±标准差表示,使用SPSS 19.0医学统计程序进行单向方差分析,P<0.05为差异有统计学.结果 HE染色及电镜检查显示在距针道相等距离位置,7.0T组及3.0T组的细胞损伤程度与高场强1.5T组相比,差异无统计学意义(P>0.05).结论 超高场强磁共振(3.0T及7.0T)并未造成DBS电极周围出现明显热损伤,提示体内植入DBS设备的患者进行超高场强磁共振扫描可能是安全的.
目的 通過對比超高場彊MRI(7.0T和3.0T)與高場彊MRI(1.5 T)下深部腦刺激(DBS)電極週圍組織的病理學變化,深入探討射頻磁場中DBS電極熱效應對週圍組織的影響.方法 雄性新西蘭白兔18隻,隨機分人7.0T組(n=6),3.0T組(n=6)及高場彊1.5T組(n=6).各組動物以左側丘腦腹後覈為靶點,植入全套DBS電極和刺激器.術後進行對應場彊覈磁共振掃描,24 h後對針道週圍腦組織進行HE染色及電鏡檢查,併對組織損傷進行評估.所有統計結果採用均數±標準差錶示,使用SPSS 19.0醫學統計程序進行單嚮方差分析,P<0.05為差異有統計學.結果 HE染色及電鏡檢查顯示在距針道相等距離位置,7.0T組及3.0T組的細胞損傷程度與高場彊1.5T組相比,差異無統計學意義(P>0.05).結論 超高場彊磁共振(3.0T及7.0T)併未造成DBS電極週圍齣現明顯熱損傷,提示體內植入DBS設備的患者進行超高場彊磁共振掃描可能是安全的.
목적 통과대비초고장강MRI(7.0T화3.0T)여고장강MRI(1.5 T)하심부뇌자격(DBS)전겁주위조직적병이학변화,심입탐토사빈자장중DBS전겁열효응대주위조직적영향.방법 웅성신서란백토18지,수궤분인7.0T조(n=6),3.0T조(n=6)급고장강1.5T조(n=6).각조동물이좌측구뇌복후핵위파점,식입전투DBS전겁화자격기.술후진행대응장강핵자공진소묘,24 h후대침도주위뇌조직진행HE염색급전경검사,병대조직손상진행평고.소유통계결과채용균수±표준차표시,사용SPSS 19.0의학통계정서진행단향방차분석,P<0.05위차이유통계학.결과 HE염색급전경검사현시재거침도상등거리위치,7.0T조급3.0T조적세포손상정도여고장강1.5T조상비,차이무통계학의의(P>0.05).결론 초고장강자공진(3.0T급7.0T)병미조성DBS전겁주위출현명현열손상,제시체내식입DBS설비적환자진행초고장강자공진소묘가능시안전적.
Objective To determine the pathological responses in tissue around the deep brain stimulation (DBS) leads in 1.5 T,3.0 T and 7.0 T magnetic resonance imaging (MRI).Methods Eighteen male Newzealand rabbits were randomly assigned to ultra-high field 7.0 T group (n =6),ultra-high field 3.0 T group (n =6) and the routine 1.5 T group (n =6).DBS devices were implanted into the rabbit brains of each group targeting the left VPN of thalamus.MRI scanning of corresponding field strength was conducted.After 24 hours,the brains were processed for HE staining and transmission electron microscopy (TEM).The results were semiquantified using our scoring system.All data were shown as mean deviation,and processed by one-way ANOVA analysis using SPSS 19.0 software.A P value less than 0.05 was considered statistically significant.Results In HE staining and TEM,the difference between the ultra-high field groups and the routine 1.5 T group was not significant (P > 0.05).Conclusions In this study,the heating of DBS lead in ultra-high field MRI scanning failed to induce more injury than in the routine 1.5 T MRI,indicating that the ultra-high magnitude MRI scanning might not be as dangerous to the patients with DBS devices as we thought.