CAJ | 학술논문

目的通过对垂体生长激素(GH)腺瘤患者手术及药物治疗疗效的回顾性分析,探讨术前使用长效生长抑素类似物在其治疗中的作用.方法回顾性分析104例资料完整的垂体GH腺瘤患者的临床特点、治疗过程及随访结果,分为单纯手术治疗组及术前应用长效生长抑素类似物(SSA)联合手术治疗组,通过比较分析术前应用长效生长抑素类似物对肿瘤体积、代谢合并症及复发等的影响.结果手术联合术前使用SSA组可实现更高的全切率(67％ vs 46％,P＜0.05),并且在糖代谢异常的改善、脂代谢异常的改善及垂体功能恢复方面均优于单纯手术组(P＜0.05).结论手术治疗能有效降低生长激素水平,改善垂体功能、糖耐量及脂代谢紊乱情况.而联合术前应用SSA可提高手术安全性、提高全切率,应用意义较大.
목적 통과대수체생장격소(GH)선류환자수술급약물치료료효적회고성분석,탐토술전사용장효생장억소유사물재기치료중적작용.방법 회고성분석104례자료완정적수체GH선류환자적림상특점、치료과정급수방결과,분위단순수술치료조급술전응용장효생장억소유사물(SSA)연합수술치료조,통과비교분석술전응용장효생장억소유사물대종류체적、대사합병증급복발등적영향.결과 수술연합술전사용SSA조가실현경고적전절솔(67％ vs 46％,P＜0.05),병차재당대사이상적개선、지대사이상적개선급수체공능회복방면균우우단순수술조(P＜0.05).결론 수술치료능유효강저생장격소수평,개선수체공능、당내량급지대사문란정황.이연합술전응용SSA가제고수술안전성、제고전절솔,응용의의교대.
Objective By retrospectively reviewing the treatment effects of surgical and/or medical intervention,we explored the effects of preoperative application of long-acting somatostatin analogs (SSAs) in patients with growth-hormone (GH) secreting pituitary adenomas.Methods In this study,we reviewed patients with GH-secreting pituitary adenomas in our center between 2007 and 2013.The clinical characteristics,treatment and follow-up results of 104 cases were summarized.The patients were divided into surgery group and surgery + SSA group.With comparison between two groups,we analyzed the effects of SSA on tumor size,metabolic co-morbidities and recurrence.Results Preoperative SSA treatment could significantly improve the rate of total resection (67％ vs 46％,P ＜ 0.05),with better glucose and lipid metabolism profile and recovery of pituitary functions than those of surgery-group (P ＜ 0.05).Conclusions Surgery could effectively reduce the GH level and improve the pituitary function,glucose tolerance and lipid metabolism profile.Preoperative application of SSA allowed better safety and total resection rate of surgery,which was a valuable option for the treatment.