CAJ | 학술논문

目的研究低级别胶质瘤累及部位与手术切除后癫痫控制效果的相关性.方法回顾性分析351例低级别胶质瘤患者术前癫痫病史、肿瘤部位和术后6个月内癫痫发作情况.分析累及不同脑叶的低级别胶质瘤术前癫痫发病率以及手术全切除后患者术后癫痫的控制率.结果本研究纳入患者总的术前癫痫发生率为66.4％.累及运动区的低级别胶质瘤最易引起癫痫(87.9％).肿瘤全切除术使71.8％累及运动区低级别胶质瘤患者的癫痫症状得到有效控制.结论通过比较手术前后患者癫痫情况,得出手术全切除可以明显缓解低级别胶质瘤占位引起的癫痫症状,并且对于累及运动区的低级别胶质瘤患者癫痫缓解效果明显.
목적 연구저급별효질류루급부위여수술절제후전간공제효과적상관성.방법 회고성분석351례저급별효질류환자술전전간병사、종류부위화술후6개월내전간발작정황.분석루급불동뇌협적저급별효질류술전전간발병솔이급수술전절제후환자술후전간적공제솔.결과 본연구납입환자총적술전전간발생솔위66.4％.루급운동구적저급별효질류최역인기전간(87.9％).종류전절제술사71.8％루급운동구저급별효질류환자적전간증상득도유효공제.결론 통과비교수술전후환자전간정황,득출수술전절제가이명현완해저급별효질류점위인기적전간증상,병차대우루급운동구적저급별효질류환자전간완해효과명현.
Objective The mechanism of tumor-related epilepsy was still far from clear.The objective of this study was to investigate the relationship between the tumor location and postoperative control of epilepsy in patients with pathologically diagnosed WHO grade Ⅱ low-grade gliomas.Methods We retrospectively collected 351 patients who were pathologically diagnosed as low-grade gliomas and underwent primary surgical treatment.The preoperative incidences of tumor-related epilepsy and postoperative incidences of tumor-related epilepsy at six months of follow-up were analyzed and were compared between patients harboring tumors in various brain regions.The rate of seizure control was calculated in patients underwent gross-total tumor resection.Results 66.4％ of patients included in this study had a history of preoperative seizures.The low-grade gliomas located in the motor areas,including primary motor area,supplementary motor area and premotor area,caused relatively higher incidence of epilepsy (87.9％) compared with tumors located in other brain regions.Following surgical resection,up to 71.8％ of patients with tumors that located in the motor areas achieved a satisfied control of tumor-related epilepsy at sixth month after the tumor resection.This percentage was higher than that in cases with low-grade gliomas locating at other brain regions.Conclusion The gross-total resection was an effective treatment in reducing the incidence of epilepsy induced by low-grade gliomas.Patients with tumors that located in the motor areas acquired the greatest benefit of seizure control from the surgical resection.