CAJ | 학술논문

目的探讨三维适形放疗(3D-CRT)联合立体定向放射外科(SRS)推量治疗手术切除后颅内血管周细胞瘤(HPC)的疗效. 方法广东三九脑科医院肿瘤综合治疗中心自2008年10月1日至2011年11月30日应用3D-CRT联合SRS推量治疗6例手术切除术后的颅内HPC患者,回顾性分析患者的临床表现、病理学特征、影像学表现和疗效. 结果 HPC患者的发病年龄在33～55岁之间,中位年龄46.5岁.临床表现主要为颅内压增高症状和肿瘤压迫、破坏周围组织所导致的局灶性症状；病理染色显示瘤细胞密集,呈纺锤形或多角形,胞膜不清,胞质略嗜酸性,可见核异型及核分裂;所有患者术后接受3D-CRT联合SRS推量治疗,随访14-44个月,2例完全缓解,4例部分缓解. 结论 HPC预后不良,易复发,偶有全身转移,手术切除是最佳治疗手段.对部分切除术后的患者,3D-CRT联合SRS推量可能进一步提高疗效.
목적 탐토삼유괄형방료(3D-CRT)연합입체정향방사외과(SRS)추량치료수술절제후로내혈관주세포류(HPC)적료효. 방법 엄동삼구뇌과의원종류종합치료중심자2008년10월1일지2011년11월30일응용3D-CRT연합SRS추량치료6례수술절제술후적로내HPC환자,회고성분석환자적림상표현、병이학특정、영상학표현화료효. 결과 HPC환자적발병년령재33～55세지간,중위년령46.5세.림상표현주요위로내압증고증상화종류압박、파배주위조직소도치적국조성증상；병리염색현시류세포밀집,정방추형혹다각형,포막불청,포질략기산성,가견핵이형급핵분렬;소유환자술후접수3D-CRT연합SRS추량치료,수방14-44개월,2례완전완해,4례부분완해. 결론 HPC예후불량,역복발,우유전신전이,수술절제시최가치료수단.대부분절제술후적환자,3D-CRT연합SRS추량가능진일보제고료효.
Objective To evaluate the effect of three-dimensional conformal radiotherapy (3D-CRT) combined with stereotactic radiosurgery (SRS) on central nervous system hemanyiopericytoma (HPC) after the excision surgery.Methods The clinical manifestations,pathological characteristics,imaging features and treatment efficacy of HPC were analyzed retrospectively by examining the data of 6 patients with HPC after partial resection in our hospital from October 1,2008 to November 30,2011.Results Age of the HPC patients ranged from 33 to 55 years (median 46.5 years).The main clinical manifestations included intracranial hypertension and focal symptoms caused by tumor oppression and destruction of the surrounding tissue.Pathological staining showed intensive tumor cells with spindle or polygonal shapes; the cell membrane was unclear; the cytoplasm was slightly eosinophilic; nuclear atypia and nuclear fission were visible.Follow up was performed in all the patients with 1 periods ranged from 14 to 44 months,showing 2 patients achieved complete remission and 4 partial remission.Conclusion HPC is an infrequent tumor of the central nervous system and has tendencies of recurrence and metastasis; Surgical resection is the best treatment; for the patients after partial resection,3D-CRTcombined with SRS is likely to further improve the therapeutic effect.