中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2013年
7期
685-690
,共6页
史菁菁%李晓蕾%于锋%张永%廖清船
史菁菁%李曉蕾%于鋒%張永%廖清船
사정정%리효뢰%우봉%장영%료청선
癫痫%基因多态性%ATP结合盒B亚家族成员1转运蛋白基因%耐药性%Meta分析
癲癇%基因多態性%ATP結閤盒B亞傢族成員1轉運蛋白基因%耐藥性%Meta分析
전간%기인다태성%ATP결합합B아가족성원1전운단백기인%내약성%Meta분석
Epilepsy%ATP-binding cassette subfamily B member 1 transporter gene%Pharmacoresistance%Meta-analysis
目的 运用Meta分析的方法综合评价ATP结合盒B亚家族成员1转运蛋白基因(ABCB1)C3435T多态性与癫痫耐药的相关性. 方法 制定原始文献的纳入和排除标准及检索策略,检索中外文数据库,收集有关ABCB1 C3435T多态性与抗癫痫药物(AEDs)治疗反应相关性的研究报告,采用等位基因型(C vs T)以及共显性模型(CC vs TT,CT vs TT)、显性模型(CC+CT vs TT)和隐性模型(CC vs CT+TT)等基因遗传模型进行对比与定量综合分析,同时按人种所属地域(亚裔人与白种人)进行亚组分析. 结果 共23篇文献纳入Meta分析,包括3704例癫痫耐药患者和4160例治疗有效患者,入选文献无发表偏倚.统计分析显示:C3435T位点多态性与癫痫耐药无统计学关联；等位基因C与T相比,随机效应模型:OR=1.05,95％ CI:0.94～1.18,P=0.390.各基因型对比以及进行亚组分析后也未发现统计学关联. 结论 ABCB1 C3435T多态性与癫痫耐药无关联.
目的 運用Meta分析的方法綜閤評價ATP結閤盒B亞傢族成員1轉運蛋白基因(ABCB1)C3435T多態性與癲癇耐藥的相關性. 方法 製定原始文獻的納入和排除標準及檢索策略,檢索中外文數據庫,收集有關ABCB1 C3435T多態性與抗癲癇藥物(AEDs)治療反應相關性的研究報告,採用等位基因型(C vs T)以及共顯性模型(CC vs TT,CT vs TT)、顯性模型(CC+CT vs TT)和隱性模型(CC vs CT+TT)等基因遺傳模型進行對比與定量綜閤分析,同時按人種所屬地域(亞裔人與白種人)進行亞組分析. 結果 共23篇文獻納入Meta分析,包括3704例癲癇耐藥患者和4160例治療有效患者,入選文獻無髮錶偏倚.統計分析顯示:C3435T位點多態性與癲癇耐藥無統計學關聯；等位基因C與T相比,隨機效應模型:OR=1.05,95％ CI:0.94～1.18,P=0.390.各基因型對比以及進行亞組分析後也未髮現統計學關聯. 結論 ABCB1 C3435T多態性與癲癇耐藥無關聯.
목적 운용Meta분석적방법종합평개ATP결합합B아가족성원1전운단백기인(ABCB1)C3435T다태성여전간내약적상관성. 방법 제정원시문헌적납입화배제표준급검색책략,검색중외문수거고,수집유관ABCB1 C3435T다태성여항전간약물(AEDs)치료반응상관성적연구보고,채용등위기인형(C vs T)이급공현성모형(CC vs TT,CT vs TT)、현성모형(CC+CT vs TT)화은성모형(CC vs CT+TT)등기인유전모형진행대비여정량종합분석,동시안인충소속지역(아예인여백충인)진행아조분석. 결과 공23편문헌납입Meta분석,포괄3704례전간내약환자화4160례치료유효환자,입선문헌무발표편의.통계분석현시:C3435T위점다태성여전간내약무통계학관련；등위기인C여T상비,수궤효응모형:OR=1.05,95％ CI:0.94～1.18,P=0.390.각기인형대비이급진행아조분석후야미발현통계학관련. 결론 ABCB1 C3435T다태성여전간내약무관련.
Objective To assess the relation of ATP-binding cassette subfamily B member 1 (ABCB1) transporter gene C3435T polymorphisms and resistance to antiepileptic drugs (AEDs) in epilepsy by conducting a Meta-analysis.Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers according to the inclusion and exclusion criteria.Studies with a case-control design involving the association of ABCB1 C3435T polymorphisms and resistance to AEDs were collected and analyzed by alleles (C vs T) and genotypes with co-dominant (CC vs TT and CT vs TT),dominant (CC+CT vs TT),and recessive (CC vs CT+TT) models in overall and in ethnicity subgroups.Results A total of 23 association studies including 7864 patients (3704 drug-resistant patients and 4160 drag-responsive patients) were pooled in this Meta-analysis.The allelic association of ABCB1 C3435T with risk of resistance to AEDs was not significant under random-effects model (OR=1.05,95％CI:0.94-1.18,P=0.390) in overall analyses.Similar results were also obtained for all genetic models in the stratified analyses by ethnicity subgroups.There was no publication bias.Conclusion The polymophisms of ABCB1 C3435T may not involve in risk of resistance to AEDs in epilepsy.
