CAJ | 학술논문

目的探讨比较早发性儿童良性枕叶癫痫(EBOS)和晚发性儿童良性枕叶癫痫(LOS)的临床特点、脑电图改变、治疗及预后. 方法回顾性收集整理郑州大学第五附属医院神经外科自2007年6月至2012年6月收治的60例经临床诊断为儿童良性枕叶癫痫患儿的临床资料,并按照2001年国际抗癫痫联盟(ILAE)建议分为EBOS组(28例)与LOS组(32例),分析比较2组患儿的临床表现、脑电图特点、药物治疗的有效性等. 结果 2组患儿在性别分布、热性惊厥史及癫痫家族史方面比较差异无统计学意义(P＞0.05),但EBOS组患儿的平均发病年龄明显低于LOS组,差异有统计学意义(P＜0.05),且在发作时间、发作频率、发作方式、发作伴随症状以及发作脑电图波形方面与LOS组有明显不同.EBOS组患儿中单用抗癫痫药治疗可达到控制效果的为23例,LOS组患儿为12例,治疗效果比较差异有统计学意义(P＜0.05). 结论 EBOS与LOS在发作时间、发作频率、发作方式及发作伴随症状方面存在明显差异,这些临床特征结合发作时脑电图的波形特点可以作为区分EBOS及LOS的临床指标.
목적 탐토비교조발성인동량성침협전간(EBOS)화만발성인동량성침협전간(LOS)적림상특점、뇌전도개변、치료급예후. 방법 회고성수집정리정주대학제오부속의원신경외과자2007년6월지2012년6월수치적60례경림상진단위인동량성침협전간환인적림상자료,병안조2001년국제항전간련맹(ILAE)건의분위EBOS조(28례)여LOS조(32례),분석비교2조환인적림상표현、뇌전도특점、약물치료적유효성등. 결과 2조환인재성별분포、열성량궐사급전간가족사방면비교차이무통계학의의(P＞0.05),단EBOS조환인적평균발병년령명현저우LOS조,차이유통계학의의(P＜0.05),차재발작시간、발작빈솔、발작방식、발작반수증상이급발작뇌전도파형방면여LOS조유명현불동.EBOS조환인중단용항전간약치료가체도공제효과적위23례,LOS조환인위12례,치료효과비교차이유통계학의의(P＜0.05). 결론 EBOS여LOS재발작시간、발작빈솔、발작방식급발작반수증상방면존재명현차이,저사림상특정결합발작시뇌전도적파형특점가이작위구분EBOS급LOS적림상지표.
Objective To investigate the clinical features of children with early-onset benign occipital epilepsy (EBOS) and children with late-onset benign occipital epilepsy (LOS) and their EEG changes,treatments and prognoses.Methods Sixty children with benign occipital epilepsy,admitted to our hospital from June 2007 to June 2012,were chosen in our study; their clinical data were retrospectively analyzed.According to the recommendations of the 2001 International League against Epilepsy (ILAE),these patients were divided into EBOS group (n=28) and LOS group (n=32); the clinical manifestations,electroencephalogram (EEG) characteristics,medication effectiveness in the two groups of children were compared.Results No significant difference on gender distribution,febrile convulsion histories and family history of epilepsy was noted between the two groups (P＞0.05); however,average ages of onset in the EBOS group were significantly younger than those in the LOS group (P＜ 0.05),and the onset time,seizure frequency,attack mode,seizures associated symptoms and seizure EEG waveforms in the EBOS group were obviously different as compared with those in the LOS group.Single-drug AED treatment could have control effect in 23 of children in the EBOS group and 12 of children in the LOS group; statistical difference was noted between the two groups (P＜0.05).Conclusion The onset time,seizure frequency,attack mode and seizures associated symptoms are obvious different between children with EBOS and LOS,and combined with seizure EEG waveforms,these differences can be used to identify the two.