CAJ | 학술논문

目的分析肥大性下橄榄核变性的临床表现及磁共振特点,提高对该病变的认识,减少误诊. 方法回顾性分析徐州医学院附属医院神经内科自2009年至2012年诊治的12例肥大性下橄榄核变性患者的临床及影像学资料.12例患者中原发病变为桥脑出血5例,小脑梗死3例,小脑出血2例,中脑梗塞1例,小脑肿瘤术后1例. 结果主要临床症状腭肌阵挛7例,共济失调6例,眼球震颤5例,声音嘶哑3例,复视2例,肢体震颤2例.MRI成像均表现为下橄榄核T1WI呈等或稍低信号,T2WI呈高信号；5例FLAIR像呈高信号改变,其余患者呈等信号.左侧3例,右侧4例,双侧5例；11例体积增大. 结论肥大性下橄榄核变性发生于GMT环路被破坏后；临床主要表现为眼-腭肌阵挛;头颅MRI特征为下橄榄核区T2WI高信号改变.
목적 분석비대성하감람핵변성적림상표현급자공진특점,제고대해병변적인식,감소오진. 방법 회고성분석서주의학원부속의원신경내과자2009년지2012년진치적12례비대성하감람핵변성환자적림상급영상학자료.12례환자중원발병변위교뇌출혈5례,소뇌경사3례,소뇌출혈2례,중뇌경새1례,소뇌종류술후1례. 결과 주요림상증상악기진련7례,공제실조6례,안구진전5례,성음시아3례,복시2례,지체진전2례.MRI성상균표현위하감람핵T1WI정등혹초저신호,T2WI정고신호；5례FLAIR상정고신호개변,기여환자정등신호.좌측3례,우측4례,쌍측5례；11례체적증대. 결론 비대성하감람핵변성발생우GMT배로피파배후；림상주요표현위안-악기진련;두로MRI특정위하감람핵구T2WI고신호개변.
Objective To analyze the clinical manifestations and MRI characteristics of hypertrophic olivary degeneration (HOD) to improve our knowledge for this disease and reduce misdiagnosis.Methods Twelve patients with HOD,admitted to our hospital from 2009 to 2012,were chosen in our study; their clinical data,including onset age,protopathy and other clinical manifestations,and imaging data,including SE sequence axial T1WI,T2WI and FLAIR fast spin-echo imaging,were analyzed.Results The protopathy in these 12 patients included pontine hemorrhage in 5,cerebellar infarction in 3,cerebral hemorrhage in 2,midbrain infarction in 1 and surgery for cerebellar tumor in 1.The main clinical symptoms included palatal myoclonus in 7,ataxia in 6,ocular myoclonus in 5,glossolalia in 3,diplopia in 2 and extremity tremor in 2.The region of inferior olivary nucleus (ION)presented high intensity on T2WI and iso-or mild hypointensity on T1WI in all 12 patients.Bilateral ION showed high signals in 5 in FLAIR; enlargement of the ION in 11 patients were noted.Conclusions HOD is a pathological phenomenon that occurs after injury to the dentato-olivary pathway.Its hallmarks include hypertrophy of the olive with increased T2 signal intensity on magnetic resonance imaging,and it often manifests with oculopalatal myoclonus clinically.