中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2014年
1期
80-82
,共3页
贾安奎%刘彦轩%吉四辈%张国林%仲华%许光霞
賈安奎%劉彥軒%吉四輩%張國林%仲華%許光霞
가안규%류언헌%길사배%장국림%중화%허광하
急性一氧化碳中毒迟发脑病%急性一氧化碳中毒%血小板-白细胞聚集体
急性一氧化碳中毒遲髮腦病%急性一氧化碳中毒%血小闆-白細胞聚集體
급성일양화탄중독지발뇌병%급성일양화탄중독%혈소판-백세포취집체
Delayed encephalopathy in acute carbon monoxide poisoning%Aacute carbon monoxide poisoning%Platelet-leukocyte aggregates
目的 探讨急性一氧化碳中毒迟发脑病(DEACMP)患者外周血血小板-白细胞聚集体(PLA)水平的变化. 方法 采用流式细胞术检测新乡医学院第一附属医院自2009年10月至2012年3月收治的30例DEACMP患者急性期、稳定期以及30例急性一氧化碳中毒(ACOP)患者外周血中血小板-单核细胞聚集体(PMA)和血小板-中性粒细胞聚集体(PNA)水平,并与同期20名体检健康者(对照组)进行比较. 结果 DEACMP组、ACOP组急性期外周血PNA和PMA水平均明显高于对照组,差异有统计学意义(P<0.05),而DEACMP组与ACOP组急性期比较差异无统计学意义(P>0.05),提示DEACMP患者和ACOP患者急性期体内血小板处于活化状态,PLA水平增高.DEACMP患者急性期外周血PNA和PMA水平均明显高于稳定期,差异有统计学意义(P<0.05),提示DEACMP患者病情稳定后,血小板活化得到控制. 结论 血小板参与了DEACMP的发病机制,PLA水平变化与病情基本一致.
目的 探討急性一氧化碳中毒遲髮腦病(DEACMP)患者外週血血小闆-白細胞聚集體(PLA)水平的變化. 方法 採用流式細胞術檢測新鄉醫學院第一附屬醫院自2009年10月至2012年3月收治的30例DEACMP患者急性期、穩定期以及30例急性一氧化碳中毒(ACOP)患者外週血中血小闆-單覈細胞聚集體(PMA)和血小闆-中性粒細胞聚集體(PNA)水平,併與同期20名體檢健康者(對照組)進行比較. 結果 DEACMP組、ACOP組急性期外週血PNA和PMA水平均明顯高于對照組,差異有統計學意義(P<0.05),而DEACMP組與ACOP組急性期比較差異無統計學意義(P>0.05),提示DEACMP患者和ACOP患者急性期體內血小闆處于活化狀態,PLA水平增高.DEACMP患者急性期外週血PNA和PMA水平均明顯高于穩定期,差異有統計學意義(P<0.05),提示DEACMP患者病情穩定後,血小闆活化得到控製. 結論 血小闆參與瞭DEACMP的髮病機製,PLA水平變化與病情基本一緻.
목적 탐토급성일양화탄중독지발뇌병(DEACMP)환자외주혈혈소판-백세포취집체(PLA)수평적변화. 방법 채용류식세포술검측신향의학원제일부속의원자2009년10월지2012년3월수치적30례DEACMP환자급성기、은정기이급30례급성일양화탄중독(ACOP)환자외주혈중혈소판-단핵세포취집체(PMA)화혈소판-중성립세포취집체(PNA)수평,병여동기20명체검건강자(대조조)진행비교. 결과 DEACMP조、ACOP조급성기외주혈PNA화PMA수평균명현고우대조조,차이유통계학의의(P<0.05),이DEACMP조여ACOP조급성기비교차이무통계학의의(P>0.05),제시DEACMP환자화ACOP환자급성기체내혈소판처우활화상태,PLA수평증고.DEACMP환자급성기외주혈PNA화PMA수평균명현고우은정기,차이유통계학의의(P<0.05),제시DEACMP환자병정은정후,혈소판활화득도공제. 결론 혈소판삼여료DEACMP적발병궤제,PLA수평변화여병정기본일치.
Objective To investigate the circulating levels of platelet-leukocyte aggregates (PLA) in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).Methods The circulating levels of platelet-neutrophil aggregates (PNA) and platelet-monocyte aggregates (PMA) were quantified in 30 patients with DEACMP (DEACMP group) and 30 patients with acute carbon monoxide poisoning (ACOP group) by using flow cytometry assay,whose results were compared with those of 20 healthy subjects (controls).Results Circulating PNA and PMA levels in DEACMP group and ACOP group at acute stage were significantly higher than those in controls,respectively (P<0.05),while no significant difference was noted between ACOP group and DEACMP group at acute stage (P>0.05),indicating that platelets were in activation status and PLA levels raised significantly in patients with DEACMP and ACOP at acute stage.Circulating PNA and PMA levels were significantly higher in DEACMP group at acute stage than those in DEACMP group at stable stage (P< 0.05),suggesting that platelet activation were controlled after the illness state were stabilized in patients with DEACMP.Conclusion Platelet is involved in the pathogenesis of DEACMP and the change trend of circulating PLA levels is basically consistent with illness state.