CAJ | 학술논문

目的探讨重症肌无力(MG)危象患者血清titin抗体检测的临床意义. 方法选择自2008年7月至2010年8月在解放军第309医院MG治疗中心就诊且确诊的MG危象患者26例为MG危象组,同期该院其他神经系统疾病(OND)患者30例为OND组,同期该院健康体检者30例为对照组.应用酶联免疫吸附法(ELISA)检测3组成员血清titin抗体水平,观察titin抗体与MG危象患者临床特征及预后转归的关系. 结果 MG危象组、OND组titin抗体阳性率分别为73.1％、3.3％,健康对照者titin抗体为阴性,差异有统计学意义(x2=51.922,P=.000);50岁以上(含50岁)MG危象患者titin抗体阳性率明显高于50岁以下患者,差异有统计学意义(x2=5.052,P=0.014);不同性别、Osserman分型及胸腺病理类型患者titin抗体阳性率差异无统计学意义(P＞0.05).治疗后titin抗体滴度下降,与治疗前比较差异有统计学意义(P＜0.05). 结论 MG危象患者血清titin抗体阳性率偏高,且与患者病情严重程度有关,对于判断MG危象患者的临床转归有一定的参考价值.
목적 탐토중증기무력(MG)위상환자혈청titin항체검측적림상의의. 방법 선택자2008년7월지2010년8월재해방군제309의원MG치료중심취진차학진적MG위상환자26례위MG위상조,동기해원기타신경계통질병(OND)환자30례위OND조,동기해원건강체검자30례위대조조.응용매련면역흡부법(ELISA)검측3조성원혈청titin항체수평,관찰titin항체여MG위상환자림상특정급예후전귀적관계. 결과 MG위상조、OND조titin항체양성솔분별위73.1％、3.3％,건강대조자titin항체위음성,차이유통계학의의(x2=51.922,P=.000);50세이상(함50세)MG위상환자titin항체양성솔명현고우50세이하환자,차이유통계학의의(x2=5.052,P=0.014);불동성별、Osserman분형급흉선병리류형환자titin항체양성솔차이무통계학의의(P＞0.05).치료후titin항체적도하강,여치료전비교차이유통계학의의(P＜0.05). 결론 MG위상환자혈청titin항체양성솔편고,차여환자병정엄중정도유관,대우판단MG위상환자적림상전귀유일정적삼고개치.
Objective To measure the clinical significance of serum Titin antibody measurement in patients with myasthenia gravis (MG) crisis.Methods Twenty six patients with MG crisis,30 patients with other neurologieal diseases (ONDs) and 30 health controls,collected in our hospital from July 2008 to August 2010,were chosen in our study; the sera level oftitin antibody was deetected by enzyme-linked immunosorbentassay (ELISA); correlations of titin antibody level with the clinical features and prognosis of the patients with MG crisis were analyzed.Results The positive rate of titin antibodies in MG crisis group and ONDs group was 73.1％ and 3.3％,and it was negative in health control group; significant differece was noted (x2=51.922,P=0.000).The positive rate of titin antibodies in patients older than 50 years of the MG crisis group was signifcantly higher than that in patients younger than 50 years (x2=5.052,P=0.014); the positive rate of titin antibodies in MG crisis group was negatively correlated to the gender of the patients,the types of Osserman and the pathological types (P＞0.05).The titin antibody titer after treatment was significantly decreased as compared with that before treatment (P＜0.05).Conclusion Positive titin antibody is mostly found in MG crisis and it's level is related to the severity of MG crisis,indicating that it might be beneficial for evaluating prognosis of MG patients.