CAJ | 학술논문

目的评价长春西汀(开文通)治疗急性脑梗死的疗效与安全性. 方法选择自2010年7月31日至2012年11月27日北京军区总医院等17家医院收治的急性脑梗死患者共610例,经纳入及排除标准遴选后,分成试验组(469例)、对照组(141例).对照组常规给予口服抗血小板聚集药物.试验组在对照组给药基础上给予长春西汀注射液(开文通)30 mg稀释于生理盐水中,缓慢静脉滴注,每天1次,连续14d.采用简易精神状态量表(MMSE)、美国国立卫生研究院卒中量表(NIHSS)、改良的Rankin量表(mRS)及Barthel指数评价疗效. 结果治疗后14 d,mRS评分试验组(1.85±1.28)优于对照组(1.97±1.23),差异有统计学意义(P＜0.05).治疗后90 d试验组MMSE量表评分(27.42±5.24)、动态NIHSS评分(1.37±2.08)和Barthel指数(7.21±17.29)都明显优于对照组[(25.59±7.36)、(2.63±4.98)和(80.60±25.06)],差异有统计学意义(P＜0.05).治疗后14d试验组与对照组生化指标比较,差异无统计学意义(P＞0.05). 结论长春西汀(开文通)治疗急性脑梗死患者是安全有效的.
목적 평개장춘서정(개문통)치료급성뇌경사적료효여안전성. 방법 선택자2010년7월31일지2012년11월27일북경군구총의원등17가의원수치적급성뇌경사환자공610례,경납입급배제표준린선후,분성시험조(469례)、대조조(141례).대조조상규급여구복항혈소판취집약물.시험조재대조조급약기출상급여장춘서정주사액(개문통)30 mg희석우생리염수중,완만정맥적주,매천1차,련속14d.채용간역정신상태량표(MMSE)、미국국립위생연구원졸중량표(NIHSS)、개량적Rankin량표(mRS)급Barthel지수평개료효. 결과 치료후14 d,mRS평분시험조(1.85±1.28)우우대조조(1.97±1.23),차이유통계학의의(P＜0.05).치료후90 d시험조MMSE량표평분(27.42±5.24)、동태NIHSS평분(1.37±2.08)화Barthel지수(7.21±17.29)도명현우우대조조[(25.59±7.36)、(2.63±4.98)화(80.60±25.06)],차이유통계학의의(P＜0.05).치료후14d시험조여대조조생화지표비교,차이무통계학의의(P＞0.05). 결론 장춘서정(개문통)치료급성뇌경사환자시안전유효적.
Objective To investigate the efficacy and safety of vinpocetine (Cavinton) in treatment of patients with acute cerebral infarction.Methods Six hundred and ten patients with acute cerebral infarction (within 48 h to 14 d of onset),admitted to 17 hospitals from July 31,2010 to November 27,2012,were recruited and randomly allocated into 2 groups:control group (n=141) and therapy group (n=469).Patients in the control group were treated with citicoline for 14 d,and those in the therapy group were treated with citicoline combined with 30 mg cavinton via intravenous drip once daily for 14 d.The outcomes were evaluated according to Mini-mental State Examination (MMSE),National Institute of Heath Stroke Scale (NIHSS),modified Rankin scale (mRS) and Barthel index before treatment and 7,14 and 90 d after symptom onset,respectively.Results Significant difference in mRS scores was noted between therapy group (1.85±1.28) and control group (1.97±1.23) 14 d after treatment (P＜0.05).There were significant differences in scores of MMSE,NIHSS and Barthel index between therapy group (27.42±5.24,1.37±2.08 and 7.21 ±17.29) and control group (25.59±7.36,2.63±4.98 and 80.60±25.06) 90 d after treatment (P＜0.05).No significant differences in blood biochemical indicators were noted between therapy group and control group (P＞0.05).Conclusion Treatment with vinpoccetine in patients with acute cerebral infarction is effective.