中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2014年
4期
398-401
,共4页
陈健%邹丽萍%赵锰%鞠俊
陳健%鄒麗萍%趙錳%鞠俊
진건%추려평%조맹%국준
癫痫%奥卡西平%口服混悬液%学龄前儿童%自身对照
癲癇%奧卡西平%口服混懸液%學齡前兒童%自身對照
전간%오잡서평%구복혼현액%학령전인동%자신대조
Epilepsy%Oxcarbazepine%Oral suspension%Preschool-aged children%Self-control study
目的 观察奥卡西平混悬液治疗学龄前儿童部分性癫痫的疗效、耐受性和安全性.方法 选择解放军总医院儿童医学中心自2009年8月至2012年8月诊治的48例学龄前部分性癫痫患儿,应用奥卡西平混悬液治疗,起始剂量10 mg/(kg·d),维持剂量30～40 mg/(kg·d).以治疗前3个月癫痫发作的频率为对照,对治疗后3个月、6个月内的疗效、不良反应、耐受性及安全性进行自身对照观察.疗效判定标准:癫痫发作减少100％为完全控制;减少75％～99％为显效;减少50％～74％为好转;减少＜50％为无效.结果 治疗3、6个月后完全控制率分别为41.7％、50％,总有效率(完全控制+显效+好转)分别是79.2％、79.2％.治疗6个月内,3例因皮疹退出(6.3％);发生不良反应12例(25％),不良反应为皮疹、睡眠增多、纳差、视物模糊;多数不良反应持续时间短且症状轻微.结论 奥卡西平混悬液治疗学龄前儿童部分性癫痫安全可靠,不良反应小,依从性好.
目的 觀察奧卡西平混懸液治療學齡前兒童部分性癲癇的療效、耐受性和安全性.方法 選擇解放軍總醫院兒童醫學中心自2009年8月至2012年8月診治的48例學齡前部分性癲癇患兒,應用奧卡西平混懸液治療,起始劑量10 mg/(kg·d),維持劑量30～40 mg/(kg·d).以治療前3箇月癲癇髮作的頻率為對照,對治療後3箇月、6箇月內的療效、不良反應、耐受性及安全性進行自身對照觀察.療效判定標準:癲癇髮作減少100％為完全控製;減少75％～99％為顯效;減少50％～74％為好轉;減少＜50％為無效.結果 治療3、6箇月後完全控製率分彆為41.7％、50％,總有效率(完全控製+顯效+好轉)分彆是79.2％、79.2％.治療6箇月內,3例因皮疹退齣(6.3％);髮生不良反應12例(25％),不良反應為皮疹、睡眠增多、納差、視物模糊;多數不良反應持續時間短且癥狀輕微.結論 奧卡西平混懸液治療學齡前兒童部分性癲癇安全可靠,不良反應小,依從性好.
목적 관찰오잡서평혼현액치료학령전인동부분성전간적료효、내수성화안전성.방법 선택해방군총의원인동의학중심자2009년8월지2012년8월진치적48례학령전부분성전간환인,응용오잡서평혼현액치료,기시제량10 mg/(kg·d),유지제량30～40 mg/(kg·d).이치료전3개월전간발작적빈솔위대조,대치료후3개월、6개월내적료효、불량반응、내수성급안전성진행자신대조관찰.료효판정표준:전간발작감소100％위완전공제;감소75％～99％위현효;감소50％～74％위호전;감소＜50％위무효.결과 치료3、6개월후완전공제솔분별위41.7％、50％,총유효솔(완전공제+현효+호전)분별시79.2％、79.2％.치료6개월내,3례인피진퇴출(6.3％);발생불량반응12례(25％),불량반응위피진、수면증다、납차、시물모호;다수불량반응지속시간단차증상경미.결론 오잡서평혼현액치료학령전인동부분성전간안전가고,불량반응소,의종성호.
Objective To evaluate the efficacy,tolerability and safety of oxcarbazepine oral suspension in partial epilepsy of preschool-aged children.Methods Forty-eight preschool-aged children with partial epilepsy,admitted to out hospital from August 2009 to August 2012,were chosen in our study; they were treated with oxcarbazepine oral suspension with an initial dose of 10 mg/(kg?d),and a maintenance dose of 30-40 mg/(kg,d).The efficacy,adverse reactions,tolerability and safety 3 and 6 months after treatment were investigated,and compared with the controls (the frequency of epileptic seizures of these children 3 months before treatment).The treatment outcomes were evaluated by seizure frequency as completely seizure free (100％ seizure reduction),markedly effective (75％-99％ seizure reduction),effective (50％-74％ seizure reduction) and invalid (＜50％ seizure reduction).Results The completely seizure free rates for 3 and 6 months after treatment were 41.7％ and 50％,and the total effective rates (completely seizure free+ markedly effective+ effective) were 79.2％ and 79.2％.Three patients gave up treatment because of rash.Adverse reactions occurred in 12 patients (25％),including rash,increased sleep,anorexia and blurred vision,which were transient and mild.Conclusion Treatment of oxcarbazepine oral suspension is safe and reliable on epilepsy with mild adverse reactions and good compliance in preschool-age children.
