CAJ | 학술논문

目的系统评价左乙拉西坦(LEV)和托吡酯(TPM)治疗癫痫的临床疗效与安全性.方法计算机检索2003～2013年Cochrane图书馆、PubMed、EMBASE、SCIE数据库和中国生物医学文献数据库、中国全文期刊数据库、中国知网、万方数据库收录的LEV、TPM治疗癫痫的相关文献,筛选随机对照试验(RCT),提取资料进行质量评价并采用RevMan 5.0软件进行Meta分析.结果共纳入6个RCT,包括1588例病例,其中LEV组648例、TPM组940例.Meta分析表明LEV组与TMP组患者用药后总体有效率的比较差异无统计学意义(OR=0.82,95％CI:0.63～1.07,P=0.150);TMP组认知障碍发生明显高于LEV组,差异有统计学意义(OR=0.73,95％CI:0.56～0.94,P=0.020). 结论在癫痫临床用药治疗过程中,LEV和TPM的总体疗效相当,但TPM对癫痫患者认知障碍损害的发生几率高于LEV,安全性较低.
목적 계통평개좌을랍서탄(LEV)화탁필지(TPM)치료전간적림상료효여안전성.방법 계산궤검색2003～2013년Cochrane도서관、PubMed、EMBASE、SCIE수거고화중국생물의학문헌수거고、중국전문기간수거고、중국지망、만방수거고수록적LEV、TPM치료전간적상관문헌,사선수궤대조시험(RCT),제취자료진행질량평개병채용RevMan 5.0연건진행Meta분석.결과 공납입6개RCT,포괄1588례병례,기중LEV조648례、TPM조940례.Meta분석표명LEV조여TMP조환자용약후총체유효솔적비교차이무통계학의의(OR=0.82,95％CI:0.63～1.07,P=0.150);TMP조인지장애발생명현고우LEV조,차이유통계학의의(OR=0.73,95％CI:0.56～0.94,P=0.020). 결론 재전간림상용약치료과정중,LEV화TPM적총체료효상당,단TPM대전간환자인지장애손해적발생궤솔고우LEV,안전성교저.
Objective To evaluate the clinical treatment efficacy and safety of levetiracetam (LEV) versus topiramate (TPM) in epilepsy.Methods Cochrane Database of Systematic Reviews,EMbase,PubMed,SCIE,CNKI,Chinese periodical full-text database,Chinese Biomedical Literature Database and Wanfang Database were used to select the related literature about epilepsy treated with levetiracetam and topiramate published from 2003 to 2013; randomized controlled trials (RCTs) were selected.The Cochrane Collaboration RevMan5.0 software was used for data analysis.Results Six RCTs involving 1588 patients were included with all trials published in English,among which 648 accepted LEV treatment and 940 accepted TPM treatment.Meta analysis results showed no statistically significant differences on the total effective rate between the TEV and TMP treatment groups (OR=0.82,95％CI=[0.63-1.07],P=0.150).But there were differences on cognitive disorders between the two groups (OR=0.73,95％CI=[0.56-0.94],P=0.020).Conclusion It seems that LEV and TPM have equal efficacy in the clinical medication treatment for epilepsy; however,LEV treatment has higher risk of causing cognitive abnormalities than TPM treatment.