CAJ | 학술논문

目的探讨非症状性颈动脉狭窄行颈动脉支架植入前后脑葡萄糖代谢率的变化.方法依据相关标准,在南京卒中注册系统中筛选出自2010年3月至12月连续登记的11例接受颈动脉支架植入术的非症状性颈动脉狭窄患者.所有患者术前及术后3个月分别进行PET-CT检查(18F-FDG示踪),采用感兴趣区法记录各动脉供血区脑葡萄糖的标准摄取最大值,并应用统计学方法比较术前术后患侧颈动脉区域脑代谢值及与对侧比较. 结果术前患侧颈动脉区域脑葡萄糖标准摄取最大值平均值为(4.99±0.96),明显低于对侧(5.67±1.27),差异有统计学意义(P＜0.05).随访时患侧颈动脉区域脑葡萄糖标准摄取最大值平均值为(5.83±l10),较术前明显提高,差异有统计学意义(P＜0.05),但与术后对侧(5.85±1.08)比较差异无统计学意义(P＞0.05). 结论非症状性颈动脉狭窄患侧脑葡萄糖代谢率显著降低,而行颈动脉支架植入术能明显改善患侧脑葡萄糖代谢率.
목적 탐토비증상성경동맥협착행경동맥지가식입전후뇌포도당대사솔적변화.방법 의거상관표준,재남경졸중주책계통중사선출자2010년3월지12월련속등기적11례접수경동맥지가식입술적비증상성경동맥협착환자.소유환자술전급술후3개월분별진행PET-CT검사(18F-FDG시종),채용감흥취구법기록각동맥공혈구뇌포도당적표준섭취최대치,병응용통계학방법비교술전술후환측경동맥구역뇌대사치급여대측비교. 결과 술전환측경동맥구역뇌포도당표준섭취최대치평균치위(4.99±0.96),명현저우대측(5.67±1.27),차이유통계학의의(P＜0.05).수방시환측경동맥구역뇌포도당표준섭취최대치평균치위(5.83±l10),교술전명현제고,차이유통계학의의(P＜0.05),단여술후대측(5.85±1.08)비교차이무통계학의의(P＞0.05). 결론 비증상성경동맥협착환측뇌포도당대사솔현저강저,이행경동맥지가식입술능명현개선환측뇌포도당대사솔.
Objective To evaluate the changes of cerebral glucose metabolism before and after carotid artery stenting (CAS) in patients with asymptomatic carotid stenosis.Methods Eleven patients,admitted to and performed CAS in our hospital from March 2010 to December 2010,were enrolled.The patients received PET-CT examination before and 3 months after CAS (tracking by 18F-FDG).The max standardized uptake value (SUVmax) of each artery supplement area was recorded by region of interest (ROI) method.The metabolism of affected carotid artery area was compared before and after CAS,and the affected carotid area and the unaffected one.Results The SUVmax before CAS in the affected carotid area (4.99±0.96) was significantly lower than that of the unaffected one (5.67±1.27,P＜0.05); follow-up SUVmax in the affected carotid area (5.83 ±1.10) was significantly increased as compared with that before CAS (P＜0.05); follow-up SUVmax in the affected carotid area showed no significant difference as compared with that in the unaffected one after CAS (5.85±1.08,P＞0.05).Conclusion The cerebral glucose metabolism of the affected carotid area decreases significantly,which could be improved after CAS.