中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2014年
9期
934-938
,共5页
李晟%刘伟%肖建新%陈秀芸
李晟%劉偉%肖建新%陳秀蕓
리성%류위%초건신%진수예
偏头痛%脑白质病变%荟萃分析
偏頭痛%腦白質病變%薈萃分析
편두통%뇌백질병변%회췌분석
Migraine%White matter abnormality%Meta-analysis
目的 探讨偏头痛与MRI脑白质异常信号的相关性. 方法 计算机检索PubMed、Ovid、维普、CNKI等数据库中关于偏头痛与MRI脑白质异常信号相关性的病例对照试验,进行Meta分析. 结果 总体评价:偏头痛患者MRI脑白质异常发生率与对照组比较有增高趋势,其比值为3.3,差异有统计学意义[Z=4.530,P=0.000,失安全系数(Nfs)=191].在对照组排除可能引起脑白质异常的其他合并疾病后,偏头痛患者MRI脑白质异常发生率较对照组高,达4.24倍,差异有统计学意义(Z=4.110,P=0.000,Nfs=124).中文文献研究中偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为4.92,差异有统计学意义(Z=3.370,P=0.001,Nfs=5).英文文献研究中偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为3.07,差异有统计学意义(Z=3.930,P=0.000,Nfs=124).伴先兆偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为3.87,差异有统计学意义(Z=3.380,P=0.001,Nfs=102).无先兆偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为2.50,差异有统计学意义(Z=3.480,P=0.001,Nfs=64). 结论 偏头痛是脑白质异常的危险因素,有先兆偏头痛较无先兆偏头痛的危险度更高.
目的 探討偏頭痛與MRI腦白質異常信號的相關性. 方法 計算機檢索PubMed、Ovid、維普、CNKI等數據庫中關于偏頭痛與MRI腦白質異常信號相關性的病例對照試驗,進行Meta分析. 結果 總體評價:偏頭痛患者MRI腦白質異常髮生率與對照組比較有增高趨勢,其比值為3.3,差異有統計學意義[Z=4.530,P=0.000,失安全繫數(Nfs)=191].在對照組排除可能引起腦白質異常的其他閤併疾病後,偏頭痛患者MRI腦白質異常髮生率較對照組高,達4.24倍,差異有統計學意義(Z=4.110,P=0.000,Nfs=124).中文文獻研究中偏頭痛患者MRI腦白質異常髮生率與對照組比較增高,其比值為4.92,差異有統計學意義(Z=3.370,P=0.001,Nfs=5).英文文獻研究中偏頭痛患者MRI腦白質異常髮生率與對照組比較增高,其比值為3.07,差異有統計學意義(Z=3.930,P=0.000,Nfs=124).伴先兆偏頭痛患者MRI腦白質異常髮生率與對照組比較增高,其比值為3.87,差異有統計學意義(Z=3.380,P=0.001,Nfs=102).無先兆偏頭痛患者MRI腦白質異常髮生率與對照組比較增高,其比值為2.50,差異有統計學意義(Z=3.480,P=0.001,Nfs=64). 結論 偏頭痛是腦白質異常的危險因素,有先兆偏頭痛較無先兆偏頭痛的危險度更高.
목적 탐토편두통여MRI뇌백질이상신호적상관성. 방법 계산궤검색PubMed、Ovid、유보、CNKI등수거고중관우편두통여MRI뇌백질이상신호상관성적병례대조시험,진행Meta분석. 결과 총체평개:편두통환자MRI뇌백질이상발생솔여대조조비교유증고추세,기비치위3.3,차이유통계학의의[Z=4.530,P=0.000,실안전계수(Nfs)=191].재대조조배제가능인기뇌백질이상적기타합병질병후,편두통환자MRI뇌백질이상발생솔교대조조고,체4.24배,차이유통계학의의(Z=4.110,P=0.000,Nfs=124).중문문헌연구중편두통환자MRI뇌백질이상발생솔여대조조비교증고,기비치위4.92,차이유통계학의의(Z=3.370,P=0.001,Nfs=5).영문문헌연구중편두통환자MRI뇌백질이상발생솔여대조조비교증고,기비치위3.07,차이유통계학의의(Z=3.930,P=0.000,Nfs=124).반선조편두통환자MRI뇌백질이상발생솔여대조조비교증고,기비치위3.87,차이유통계학의의(Z=3.380,P=0.001,Nfs=102).무선조편두통환자MRI뇌백질이상발생솔여대조조비교증고,기비치위2.50,차이유통계학의의(Z=3.480,P=0.001,Nfs=64). 결론 편두통시뇌백질이상적위험인소,유선조편두통교무선조편두통적위험도경고.
Objective To investigate the correlation between migraine and abnormal white matter signal in MR imaging.Methods The controlled trail was performed on the relevant cases selected from the data bases of PubMed,Ovid,VIP,CNKI,and then,meta-analysis was implemented.Results The general evaluation showed that patients with migraine had a high trend of abnormal white matter signal in MR imaging as compared with the normal controls (occurrence rate [OR]=3.3,Z=4.53,P=0.000 and fail-safe number [Nfs]=191).After excluding other complications those might cause abnormal white matter signal,the OR reached to 4.24 (Z=4.110,P=0.000 amd Nfs=124).As the same as the evaluation of significant difference in Chinese journals (OR=4.92,Z=3.370,P=0.001 and Nfs=5),the English journals also revealed this difference was statistically significant (OR=3.07,Z=3.930,P=0.000 and Nfs=124).The difference was significant if abnormal white matter signal was associated with migraine with aura (OR=3.870,Z=3.38,P=0.001 and Nfs=102) and without attra (OR=2.50,Z=3.482,P=0.001 and Nfs=64).Conclusion Migraine is a risk factor for white matter abnormalities; patients with migraine with aura are at greater risk than those with migraine without aura.
