CAJ | 학술논문

目的研究原发性犬颅脑爆震伤的早期病理生理机制.方法杂种雄性犬30只,按随机数字表法分为5mm致伤组,9mm致伤组及13mm致伤组,每组10只,分别距犬右颞顶部5mm、9mm、13mm引爆球型爆炸源,制作重、中、轻型颅脑爆震伤模型.观察3组犬呼吸、心率和平均动脉压(MABP)、成活时间和行为学的变化,HE染色、电镜分别观察挫伤脑组织的病理、超微结构的改变.结果犬伤后不同程度出现呼吸骤停、心率、血压下降.5mm、9mm、13mm致伤组犬呼吸暂停时间依次降低,心率和MABP下降幅度依次增加,差异均有统计学意义(P＜0.05);伤情越重,犬行为学改变越明显;HE染色、电镜显示3组犬脑组织出现不同程度的脑挫裂伤、脑出血、硬膜下血肿等病理改变.结论原发性颅脑爆震伤后犬出现生理指标下降及病理改变,伤情越重,生理指标及病理学改变越明显.
목적 연구원발성견로뇌폭진상적조기병리생리궤제.방법 잡충웅성견30지,안수궤수자표법분위5mm치상조,9mm치상조급13mm치상조,매조10지,분별거견우섭정부5mm、9mm、13mm인폭구형폭작원,제작중、중、경형로뇌폭진상모형.관찰3조견호흡、심솔화평균동맥압(MABP)、성활시간화행위학적변화,HE염색、전경분별관찰좌상뇌조직적병리、초미결구적개변.결과 견상후불동정도출현호흡취정、심솔、혈압하강.5mm、9mm、13mm치상조견호흡잠정시간의차강저,심솔화MABP하강폭도의차증가,차이균유통계학의의(P＜0.05);상정월중,견행위학개변월명현;HE염색、전경현시3조견뇌조직출현불동정도적뇌좌렬상、뇌출혈、경막하혈종등병리개변.결론 원발성로뇌폭진상후견출현생리지표하강급병리개변,상정월중,생리지표급병이학개변월명현.
Objective To investigate the early physiologic and pathologic changes of primary explosive injury to brain in dogs.Methods Thirty mongrel male dogs were randomly divided into 13 mm detonated injury group (n=10),9 mm detonated injury group (n=10) and 5 mm detonated injury group (n=10); a spherical explosive with explosive energy of 1 g TNT was used to detonate at different distances (13,9 and 5 mm) to dogs' head to cause the severe,moderate and slight degrees of craniocerebral primary explosive injury in these dogs,respectively.Changes of respiratory frequency (RF),heart rate (HR) and mean arterial blood pressure (MABP),survival time and behavior in these dogs were observed; HE staining and electron microscopy were used to observe the pathological and ultrastructural changes of the brain tissues.Results The RF,HR and MABP levels after cerebral explosive injury were decreased in dogs of three groups; the decreased extent was increased following the increase of injury extent,with significant difference among the three groups (13 mm detonated injury group＞9 mm detonated injury group＞5 mm detonated injury group,P＜0.05).The server the injury,the more obvious the changes of dog behaviors (13 mm detonated injury group＞9 mm detonated injury group＞5 mm detonated injury group,P＜0.05).There were different extents of contusion and laceration of the brains,brain hemorrhage,and subdural hematoma in the three groups.Conclusions RF,HR and BP levels are decreased in three groups after cerebral primary explosive injury in dogs; the more obvious the physiologic and pathologic changes,the severer degrees of craniocerebral explosive injury.The severer injury dogs have more obvious behavioral changes.The survival time in dogs with the severer degrees of craniocerebral explosive injury is shorter than that in slight injury one.