CAJ | 학술논문

目的探讨不同剂量阿立哌唑对5种临床常用二代抗精神病药物所致高泌乳素血症的干预治疗效果.方法 200例分别使用利培酮、奥氮平、喹硫平、帕利哌酮、齐拉西酮治疗出现高泌乳素血症的精神分裂症患者(系自2012年1月至2014年6月于中山大学附属第三医院、广州市脑科医院、广州市三九脑科医院和东莞市新涌医院收治),按随机数字表法分为合并阿立哌唑5mg组和阿立哌唑10 mg组(各100例),在原治疗所需抗精神病药物种类与剂量不变的基础上,分别给予5 mg/片、10mg/片晚上一次顿服,持续6周.检测2组患者治疗前和治疗第2、4、6周末血浆泌乳素水平,以阳性和阴性症状量表(PANSS)和副反应量表(TESS)评定治疗前和治疗第6周末的疗效与安全性.结果 (1)2组治疗第2、4周末泌乳素水平均较治疗前明显下降,差异均有统计学意义(P＜0.05),但2组间差异无统计学意义(P＞0.05);阿立哌唑5 mg组第6周末泌乳素水平较治疗前及第2、4周末仍明显下降,差异有统计学意义(P＜0.05),且与阿立哌唑10 mg组差异有统计学意义(P＜0.05).(2)2组PANSS评分在治疗第6周末均较治疗前有明显下降,差异有统计学意义(P＜0.05),但2组间差异无统计学意义(P＞0.05).(3)阿立哌唑10 mg组不良反应率明显高于阿立哌唑5mg组,差异有统计学意义(P＜0.05).结论阿立哌唑5 mg/d和10 mg/d均对临床常用二代抗精神病药物所致高泌乳素血症有不同程度的改善作用,且前者剂量更兼具疗效和安全性.
목적 탐토불동제량아립고서대5충림상상용이대항정신병약물소치고비유소혈증적간예치료효과.방법 200례분별사용리배동、오담평、규류평、파리고동、제랍서동치료출현고비유소혈증적정신분렬증환자(계자2012년1월지2014년6월우중산대학부속제삼의원、엄주시뇌과의원、엄주시삼구뇌과의원화동완시신용의원수치),안수궤수자표법분위합병아립고서5mg조화아립고서10 mg조(각100례),재원치료소수항정신병약물충류여제량불변적기출상,분별급여5 mg/편、10mg/편만상일차돈복,지속6주.검측2조환자치료전화치료제2、4、6주말혈장비유소수평,이양성화음성증상량표(PANSS)화부반응량표(TESS)평정치료전화치료제6주말적료효여안전성.결과 (1)2조치료제2、4주말비유소수평균교치료전명현하강,차이균유통계학의의(P＜0.05),단2조간차이무통계학의의(P＞0.05);아립고서5 mg조제6주말비유소수평교치료전급제2、4주말잉명현하강,차이유통계학의의(P＜0.05),차여아립고서10 mg조차이유통계학의의(P＜0.05).(2)2조PANSS평분재치료제6주말균교치료전유명현하강,차이유통계학의의(P＜0.05),단2조간차이무통계학의의(P＞0.05).(3)아립고서10 mg조불량반응솔명현고우아립고서5mg조,차이유통계학의의(P＜0.05).결론 아립고서5 mg/d화10 mg/d균대림상상용이대항정신병약물소치고비유소혈증유불동정도적개선작용,차전자제량경겸구료효화안전성.
Objective To investigate the efficacy and safety of different doses of aripirazole in second-generation antipsychotics-induced hyperprolactinemia.Methods Two hundred patients with second-generationantipsychotics (risperidone,olanzapine,quetiapine,paliperidoneandziprasidone) induced hyperprolactinemia were randomly assigned to groups of combined with aripiprazole 5 mg/d or 10 mg/d treatment,respectively.The plasma prolactin (PRL) level was measured before and 2,4 and 6 weeks after treatment,Positive and Negative Syndrome Scale (PANSS) and Treatment Emergent Symptom Scale (TESS) were used to assess the psychotic symptoms and adverse effects 6 weeks after treatment.Results The PRL level 2 and 4 weeks after treatment at both 5 mg and 10 mg aripiprazole groups was significantly lower than that of baseline (P＜0.05),but there was no statistical difference between the two groups (P＞0.05); The PRL level 6 weeks after treatment at 5 mg aripiprazole group was significantly lower than that of baseline,and 2 and 4 weeks after treatment (P＜0.05),and statistical difference was noted between the two groups 6 weeks after treatment (P＜0.05).As compared with the baseline,the PANSS scores in both groups 6 weeks after treatment showed significant reduction (P＜0.05),but there was no statistical difference between the two groups (P＞0.05).The adverse effect rate of 10 mg aripiprazole group was significantly higher than that of 5 mg aripiprazole group (P＜0.05).Conclusion Treatments with 5 mg and 10 mg of aripiprazole show improvement in hyperprolactinemia induced by second-generation antipsychotics,and 5 mg/d aripirazole is the better combination dose.