CAJ | 학술논문

目的观察乙肝病毒e抗原(HBeAg)阴性与阳性慢性乙型肝炎患者在年龄、ALT、乙肝病毒脱氧核糖核酸(HBV DNA)定量方面的特点.方法回顾性分析125例慢性乙型肝炎患者的临床资料,根据HBeAg表达情况分为HBeAg阴性与阳性慢性乙型肝炎两组,对两组患者的年龄、ALT和HBV DNA进行统计学分析.结果 125例慢性乙型肝炎患者中,HBeAg阴性组24例,占19.2％;HBeAg阳性组101例,占80.8％.两组在平均年龄、HBV DNA之间比较,差异具有统计学意义;ALT之间比较没有统计学意义.在HBeAg阴性组中,HBV DNA定量较低,随着病毒载量的增高,ALT异常的数量呈下降趋势;在HBeAg阳性组中,HBV DNA定量较高,随着病毒载量的增高,ALT异常的数量大致呈上升趋势.结论 HBeAg阴性慢性乙型肝炎患者年龄较HBeAg阳性患者高,ALT、HBVDNA定量水平低于HBeAg阳性者.随着病毒载量的增高,ALT异常的数量呈下降趋势,而后者则相反.
목적 관찰을간병독e항원(HBeAg)음성여양성만성을형간염환자재년령、ALT、을간병독탈양핵당핵산(HBV DNA)정량방면적특점.방법 회고성분석125례만성을형간염환자적림상자료,근거HBeAg표체정황분위HBeAg음성여양성만성을형간염량조,대량조환자적년령、ALT화HBV DNA진행통계학분석.결과 125례만성을형간염환자중,HBeAg음성조24례,점19.2％;HBeAg양성조101례,점80.8％.량조재평균년령、HBV DNA지간비교,차이구유통계학의의;ALT지간비교몰유통계학의의.재HBeAg음성조중,HBV DNA정량교저,수착병독재량적증고,ALT이상적수량정하강추세;재HBeAg양성조중,HBV DNA정량교고,수착병독재량적증고,ALT이상적수량대치정상승추세.결론 HBeAg음성만성을형간염환자년령교HBeAg양성환자고,ALT、HBVDNA정량수평저우HBeAg양성자.수착병독재량적증고,ALT이상적수량정하강추세,이후자칙상반.
Objective To observe the characteristics of age,alanine aminotransferase (ALT) and hepatitis B virus DNA (HBV DNA) quantitative between HBeAg-negative and HBeAg-positive patients with chronic hepatitis B.Methods The clinical datas of 125 patients with chronic hepatitis B were analyzed retrospectively.According to the expression of HBeAg,divided the chronic hepatitis B patients into two groups:HBeAg-negative and-positive.The datas of age,ALT and HBV DNA were analyzed by statistical methods.Results Among 125 patients,24 cases were HBeAg-negative group accounting for 19.2％ ; 101 cases were HBeAg-positive group accounting for 80.8％.The difference between two groups in average age and HBV DNA was significant,the comparison between ALT of two groups has no statistical significance.In HBeAg-negative groups,HBV DNA quantitative is lower,as the viral load increase,the number of abnormal ALT show a downward trend; In HBeAg positive group,HBV DNA quantitative is higher,as the viral load increase,the ALT abnormal quantity generally show a upward trend.Conclusions The age of HBeAgnegative chronic hepatitis B patients is larger than the HBeAg-positive patients,the level of ALT,HBV DNA quantitative in HBeAg-negative chronic hepatitis B patients lower than the HBeAg-positive patients,and as the viral load increase,the ALT abnormal number is on the decline,while the latter is opposite.