CAJ | 학술논문

目的探讨不同级别胶质瘤组织中水通道蛋白4(AQP4)表达水平的差异.方法取我院自2008年至2012年间胶质瘤共57例石蜡包埋的肿瘤组织及10例正常脑组织,采用免疫组化法检验其AQP4水平并行统计学检验.结果高级别胶质瘤肿瘤组织的AQP4表达水平高于低级别胶质瘤和正常脑组织的AQP4表达水平(P＜0.05),而低级别胶质瘤的肿瘤组织与正常脑组织之间的AQP4表达水平差异无统计学意义(P＞0.05).结论 AQP4在胶质瘤中的表达水平与肿瘤病理级别密切相关.
목적 탐토불동급별효질류조직중수통도단백4(AQP4)표체수평적차이.방법 취아원자2008년지2012년간효질류공57례석사포매적종류조직급10례정상뇌조직,채용면역조화법검험기AQP4수평병행통계학검험.결과 고급별효질류종류조직적AQP4표체수평고우저급별효질류화정상뇌조직적AQP4표체수평(P＜0.05),이저급별효질류적종류조직여정상뇌조직지간적AQP4표체수평차이무통계학의의(P＞0.05).결론 AQP4재효질류중적표체수평여종류병리급별밀절상관.
Objective Explore the difference of water channel protein 4 (AQP4) 's expression level in different grade glioma tissues.Methods select 57 cases of paraffin embedding glioma tissues and 10 cases of normal brain tissue in our hospital from 2008 to 2012,use immunohistochemical method to test the level of AQP4 and do statistical tests.Results The AQP4 expression level in high grade glioma tumor tissues is higher than in the low grade glioma and normal brain tissue (P ＜ 0.05),and there is no statistical significance about the difference AQP4 expression levels between low grade glioma tumor tissue and normal brain tissue (P ＞ 0.05).Conclusions AQP4 expression level in glioma is closely related to the tumor pathological level.