CAJ | 학술논문

目的了解百色市成人呼吸道感染病原学状况.方法 (1)选择391例临床诊断为呼吸道感染的门诊及住院患者,于急性期及恢复期分两次,用蛋白芯片技术检测患者血清的6种病原体:流感病毒(influenza virus,Ⅳ)、呼吸道合胞病毒(respiratory syncytial virus,RSV)、柯萨奇病毒(Coxsackievirus B,CVB)、腺病毒(adenovirus,ADV)、肺炎支原体(mycoplasmal pneumoniae,MP)、肺炎衣原体(chlamydia pneumoniae,CPN)的IgM抗体.结果 391例患者中阳性180例,总阳性率46.06％,其中MP感染为第一位占18.33％,其次是CPN感染占14.44％.混合感染中,第一为MP合并ADV感染,占7.78％;第二为MP合并CPN感染,占5.00％.感染急性期MP抗体阳性并有相关临床症状的阳性率为89.55％,感染急性期MP抗体阳性并有恢复期抗体增高4倍及以上实验室诊断的阳性率为86.57％.两个阳性率间差异无统计学意义(P＞0.05).CPN抗体也得出类似结果.结论百色市成人呼吸道感染中以ADV、MP、CPN及它们的合并感染检出率最高.急性期MP及CPN抗体阳性联合相应的临床症状诊断的阳性率与通过急性期及恢复期两次蛋白芯片法实验室确诊的阳性率,两者间差异无统计学意义.
목적 료해백색시성인호흡도감염병원학상황.방법 (1)선택391례림상진단위호흡도감염적문진급주원환자,우급성기급회복기분량차,용단백심편기술검측환자혈청적6충병원체:류감병독(influenza virus,Ⅳ)、호흡도합포병독(respiratory syncytial virus,RSV)、가살기병독(Coxsackievirus B,CVB)、선병독(adenovirus,ADV)、폐염지원체(mycoplasmal pneumoniae,MP)、폐염의원체(chlamydia pneumoniae,CPN)적IgM항체.결과 391례환자중양성180례,총양성솔46.06％,기중MP감염위제일위점18.33％,기차시CPN감염점14.44％.혼합감염중,제일위MP합병ADV감염,점7.78％;제이위MP합병CPN감염,점5.00％.감염급성기MP항체양성병유상관림상증상적양성솔위89.55％,감염급성기MP항체양성병유회복기항체증고4배급이상실험실진단적양성솔위86.57％.량개양성솔간차이무통계학의의(P＞0.05).CPN항체야득출유사결과.결론 백색시성인호흡도감염중이ADV、MP、CPN급타문적합병감염검출솔최고.급성기MP급CPN항체양성연합상응적림상증상진단적양성솔여통과급성기급회복기량차단백심편법실험실학진적양성솔,량자간차이무통계학의의.
Objective To investigate the pathogen in adult airway infection of Baise city.Method A total of 391 cases (both outpatient and inpatient)of airway infection were collected.Serum IgM titer of six pathogen(influenza virus,Ⅳ; respiratory syncytial virus,RSV; Coxsackievirus B,CVB; adenovirus,ADV ; mycoplasmal pneumoniae,MP;Chlamydia pneumoniae,CPN) were tested for two times at acute stage and convalescent period respectively.Protein chip technology was used to test the IgM antibody.Results 180 samples were positive,the total positive rate was 46.06％.the positive rate of MP was 18.33％,14.44％ for CPN.Among mixed infection,MP combined with ADV positive rate was 7.78％,5.00％ for MP combined with CPN.The positive rate for cases which MP IgM antibody was positive and had clinical symptoms at acute stage was 89.55％.The positive rate for cases which MP IgM antibody was positive at acute stage and rose 4 times at convalescent period was 86.57％.There was no significant difference between them (P ＞ O.05).We got the same result for The positive rate for CPN IgM antibody.Conclusion The positive rate for IgM antibody of common pathogen among baise adult respiratory tract infection ranked:ADV,MP,CPN.Patients whose MP or CPN IgM antibody was positive and with according clinical symptoms could be diagnosed with MP or CPN infection.