CAJ | 학술논문

目的探讨广州地区乙型肝炎病毒/丙型肝炎病毒(HBV/HCV)重叠感染患者的流行及临床特征,为提高其诊治提供依据.方法回顾2005年4月至2011年10月我院收治慢性HBV感染患者临床资料,分析HBV/HCV重叠感染患者流行特征,按照HBeAg状态以及HBV DNA、HCV RNA水平分组分析HBV/HCV重叠感染患者临床特征.结果 HBV/HCV重叠感染率为1.9％(128/6604),主要见于伴静脉吸毒史的男性中年患者.HBeAg阳性与阴性重叠感染患者之间的生化指标和终末期肝病发生率均无差异.HBeAg阳性患者HBV DNA阳性率高于阴性患者(P ＜0.001),而HCV RNA水平阳性率低于阴性患者(P =0.007).HBV DNA阳性患者终末期肝病发生率较阴性组升高(58.1％比37.9％,P=0.027),而HCV RNA阳性与阴性患者之间发生率相似(43.6％比49.2％,P=0.540).结论广州地区HBV/HCV重叠感染率较低,HBV DNA水平可能与患者的疾病进展相关.
목적 탐토엄주지구을형간염병독/병형간염병독(HBV/HCV)중첩감염환자적류행급림상특정,위제고기진치제공의거.방법 회고2005년4월지2011년10월아원수치만성HBV감염환자림상자료,분석HBV/HCV중첩감염환자류행특정,안조HBeAg상태이급HBV DNA、HCV RNA수평분조분석HBV/HCV중첩감염환자림상특정.결과 HBV/HCV중첩감염솔위1.9％(128/6604),주요견우반정맥흡독사적남성중년환자.HBeAg양성여음성중첩감염환자지간적생화지표화종말기간병발생솔균무차이.HBeAg양성환자HBV DNA양성솔고우음성환자(P ＜0.001),이HCV RNA수평양성솔저우음성환자(P =0.007).HBV DNA양성환자종말기간병발생솔교음성조승고(58.1％비37.9％,P=0.027),이HCV RNA양성여음성환자지간발생솔상사(43.6％비49.2％,P=0.540).결론 엄주지구HBV/HCV중첩감염솔교저,HBV DNA수평가능여환자적질병진전상관.
Objective To explore the epidemiological and clinical feature of hepatitis B virus and hepatitis C virus (HBV/HCV) co-infection in Guangzhou area,and provide evidence to elevate the diagnoses and treatment for the co-infection.Methods Data of patients with chronic HBV infection seen from April 2005 to October 2011 were retrospectively collected,and the epidemiological features of HBV/ HCV co-infection were analyzed.Patients with HBV/HCV co-infection were stratified according to the HBeAg status and the levels of HBV DNA and HCV RNA,and their clinical feature were analyzed.Results The prevalence of HBV/HCV co-infection was 1.9％ (128/6604),which was mainly seen in middle age of male populations with history of drug addiction.There were no significant differences in biochemical markers and percentage of end-stage liver disease between HBeAg positive and HBeAg negative co-infection patients.The HBV DNA positive rate in HBeAg positive patients was higher than those in HBeAg negative patients (P ＜ 0.001),while the HCV RNA positive rate was lower than those in HBeAg negative patients (P =0.007).The frequency of end-stage liver disease in HBV DNA positive patients was higher than that in HBV DNA negative patients (58.1％ vs.37.9％,P =0.027),but it was similar between HCV RNA positive and negative patients (43.6％ vs.49.2％,P =0.540).Conclusions The prevalence of HBV/ HCV co-infection in Guangzhou area in low,and the levels of HBV DNA may associate with progression of disease.