CAJ | 학술논문

目的目前有多种方法可以用于结核性胸腔积液的诊断.本研究比较了IFN-γ释放试验(IGRAs)、腺苷脱氨酶活性检测(ADA)和结核抗体检测(TB-ab)三种方法.方法对63例胸腔积液患者分别使用IFN-γ释放试验、腺苷脱氨酶活性检测和结核抗体检测三种方法进行鉴别诊断.IFN-γ释放试验、腺苷脱氨酶活性检测和结核抗体检测均根据厂家提供的方案进行.结果三种方法都有一定的诊断意义,但在效果上有差别.其中,结核抗体检测敏感性和特异性最低.尽管腺苷脱氨酶活性检测的特异性较高,但其仅仅检测到58.14％的患者,敏感性较低.IFN-γ释放试验检测到了79.07％的患者,并且具有较高的特异性.结论IFN-γ释放试验检测具有比腺苷脱氨酶活性检测和结核抗体检测更好的效果,推荐在结核性胸腔积液的诊断中使用IFN-γ释放试验.
목적 목전유다충방법가이용우결핵성흉강적액적진단.본연구비교료IFN-γ석방시험(IGRAs)、선감탈안매활성검측(ADA)화결핵항체검측(TB-ab)삼충방법.방법대63례흉강적액환자분별사용IFN-γ석방시험、선감탈안매활성검측화결핵항체검측삼충방법진행감별진단.IFN-γ석방시험、선감탈안매활성검측화결핵항체검측균근거엄가제공적방안진행.결과 삼충방법도유일정적진단의의,단재효과상유차별.기중,결핵항체검측민감성화특이성최저.진관선감탈안매활성검측적특이성교고,단기부부검측도58.14％적환자,민감성교저.IFN-γ석방시험검측도료79.07％적환자,병차구유교고적특이성.결론IFN-γ석방시험검측구유비선감탈안매활성검측화결핵항체검측경호적효과,추천재결핵성흉강적액적진단중사용IFN-γ석방시험.
Objective To study the effect of interferon-gamma release assays (IGRAs) adenosine deaminase activity test (ADA) and tuberculosis antibody test (TB-ab) in diagnosis of tuberculous pleurisy.Materials Sixty-three patients with pleurisy were tested for IGRAs,ADA and tuberculosis antibody.Samples of blood were tested.IGRAs,ADA and tuberculosis antibody were diagnosed according to manufacturer' s instructions.Results Either of the method could detect several patients with tuberculous pleurisy.Tuberculosis antibody showed lowest sensitivity and specificity.In our experiments,ADA test only detected 58.14％ of patients,although specificity can be high.We detected highest percentage of tuberculous pleurisy (79.07％) in blood IGRAs,with a specificity of 70％.Conclusion Blood IGRAs are more effective than blood ADA and tuberculosis antibody test,and it is recommend that IGRAs should be used in diagnosis of tuberculous pleurisy.