中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2014年
5期
367-370
,共4页
臧红%朱冰%温斌%万志红%柳芳芳%李晨%刘婉姝%游绍莉%辛绍杰
臧紅%硃冰%溫斌%萬誌紅%柳芳芳%李晨%劉婉姝%遊紹莉%辛紹傑
장홍%주빙%온빈%만지홍%류방방%리신%류완주%유소리%신소걸
肝功能衰竭,急性%肝炎/病因子%预后
肝功能衰竭,急性%肝炎/病因子%預後
간공능쇠갈,급성%간염/병인자%예후
Liver failure,acute%Hepatitis/etiology%Prognosis
目的 探讨我国北方地区急性、亚急性肝衰竭患者的病因特点及其与预后关系.方法 回顾性分析我院2002年1月至2013年12月收治的655例急性、亚急性肝衰竭患者的病因及转归的相关临床资料.结果 655例急性、亚急性肝衰竭病因构成:病毒感染仍是首要原因,占比38.17％,其次为病因不明36.95％及药物引起(22.75％).病因变迁:2002年至2005年,病毒感染是急性、亚急性肝衰竭首要病因,占比58.2％～50％,尤其是嗜肝病毒感染(HAV+ HBV+ HEV) 53.5％～44.4％.从2006年嗜肝病毒感染明显下降,而不明原因及药物所致呈逐步上升趋势,在2009年不明原因取代病毒感染成为最主要病因.患者总体改善率为34.81％,其中HEV感染所致的预后好于不明原因(P＜0.05).结论我国北方地区急性、亚急性肝衰竭病因构成发生改变,不明原因所致逐渐增多并取代病毒感染成为最主要病因,不同病因预后不同.
目的 探討我國北方地區急性、亞急性肝衰竭患者的病因特點及其與預後關繫.方法 迴顧性分析我院2002年1月至2013年12月收治的655例急性、亞急性肝衰竭患者的病因及轉歸的相關臨床資料.結果 655例急性、亞急性肝衰竭病因構成:病毒感染仍是首要原因,佔比38.17％,其次為病因不明36.95％及藥物引起(22.75％).病因變遷:2002年至2005年,病毒感染是急性、亞急性肝衰竭首要病因,佔比58.2％～50％,尤其是嗜肝病毒感染(HAV+ HBV+ HEV) 53.5％～44.4％.從2006年嗜肝病毒感染明顯下降,而不明原因及藥物所緻呈逐步上升趨勢,在2009年不明原因取代病毒感染成為最主要病因.患者總體改善率為34.81％,其中HEV感染所緻的預後好于不明原因(P＜0.05).結論我國北方地區急性、亞急性肝衰竭病因構成髮生改變,不明原因所緻逐漸增多併取代病毒感染成為最主要病因,不同病因預後不同.
목적 탐토아국북방지구급성、아급성간쇠갈환자적병인특점급기여예후관계.방법 회고성분석아원2002년1월지2013년12월수치적655례급성、아급성간쇠갈환자적병인급전귀적상관림상자료.결과 655례급성、아급성간쇠갈병인구성:병독감염잉시수요원인,점비38.17％,기차위병인불명36.95％급약물인기(22.75％).병인변천:2002년지2005년,병독감염시급성、아급성간쇠갈수요병인,점비58.2％～50％,우기시기간병독감염(HAV+ HBV+ HEV) 53.5％～44.4％.종2006년기간병독감염명현하강,이불명원인급약물소치정축보상승추세,재2009년불명원인취대병독감염성위최주요병인.환자총체개선솔위34.81％,기중HEV감염소치적예후호우불명원인(P＜0.05).결론아국북방지구급성、아급성간쇠갈병인구성발생개변,불명원인소치축점증다병취대병독감염성위최주요병인,불동병인예후불동.
Objective To investigate the etiological characteristics and prognosis of patients with acute liver failure(ALF) and subacute liver failure (SALF) from northern China.Methods The clinical data about etiologies and outcomes of 655 patients with ALF and SALF were retrospectively analyzed.Results The etiological constituent ratio of 655 patients with ALF and SALF:viral infection is primary (38.17％),followed by unknown etiology(36.95％) and drug-induced(22.75％).The etiology of ALF and SALF is changed,the main cause is viral infection (58.2％-50％) from 2002 to 2005,there into hepatotropic virus was dominant (53.5％-44.4％).But hepatotropic virus infection were decreased from 2006,unknown etiology and drug-induced were increased gradually.Unknown etiology has replaced viral infection as the most common cause of ALF and SALF.The overall improved rate of ALF and SALF was 34.81％,The prognosis of HEY-infected is significantly better than that of unknown etiology(P ＜ 0.05).Conclusions The etiological constituent ratio of ALF and SALF has changed in northern China,the unknown etiology of ALF and SALF was increased and replaced viral infection as the most common cause.The prognosis of acute and subacute liver failure varies in different etiology.
