CAJ | 학술논문

目的探讨磁共振(MR)淋巴管造影在评价兔肢体淋巴水肿的淋巴管形态和功能方面的诊断价值.方法新西兰大白兔一侧后肢制备淋巴水肿模型6只,另一侧作为对照.模型成功4周后,双侧后肢趾蹼皮内注射钆贝葡胺注射液各0.6ml进行MR造影检查,3 d后行淋巴闪烁造影(Las)检查作为对照.结果成功构建6只兔后肢淋巴水肿模型.MR淋巴造影显示阻塞区远端淋巴管典型阻塞征象,皮下毛细淋巴管呈不规则的网状结构,侧支淋巴管随造影时间延长呈明显增多趋势.患侧淋巴回流功能较差,阻塞处造影剂影像强度随时间延长而增强,消失缓慢.而健侧造影剂显像后很快消失,反应淋巴回流功能良好,两者间强化曲线呈现明显差异.结论 MR淋巴管造影较LAS更能准确定位淋巴管阻塞部位,清楚反映淋巴管的形态及阻塞程度.造影剂在阻塞部位信号强度随时间逐渐增强而消失缓慢,健侧则显影后很快消失,对量化评价淋巴管功能更具有优势.
목적 탐토자공진(MR)림파관조영재평개토지체림파수종적림파관형태화공능방면적진단개치.방법 신서란대백토일측후지제비림파수종모형6지,령일측작위대조.모형성공4주후,쌍측후지지복피내주사구패포알주사액각0.6ml진행MR조영검사,3 d후행림파섬삭조영(Las)검사작위대조.결과 성공구건6지토후지림파수종모형.MR림파조영현시조새구원단림파관전형조새정상,피하모세림파관정불규칙적망상결구,측지림파관수조영시간연장정명현증다추세.환측림파회류공능교차,조새처조영제영상강도수시간연장이증강,소실완만.이건측조영제현상후흔쾌소실,반응림파회류공능량호,량자간강화곡선정현명현차이.결론 MR림파관조영교LAS경능준학정위림파관조새부위,청초반영림파관적형태급조새정도.조영제재조새부위신호강도수시간축점증강이소실완만,건측칙현영후흔쾌소실,대양화평개림파관공능경구유우세.
Objective To evaluate the feasibility of high-resolution MR lymphangiography with intracutaneous injection of gadodiamide, a commercially available, nonionic, extracellular paramagnetic con-trast agent,for the visualization of lymphatic vessels in lymphedema.Methods Post-surgical lymphedema was experimentally created in one hide limb of 6 rabbits.Another hide leg of each rabbit was used as the normal control.Four weeks later, normal and lymphedematous rabbit limbs were imaged following direct subcutaneous administration of gadobenate dimeglumine injection, 0.6 ml/limb.Images were obtained on axial and coronal planes with a Tl-weighted spin echo inversion-recovery sequence.Three days after above MR lymphangiography examination, LAS examination was applied as control.Results In the normal limb,collecting lymphatics and lymph node were clearly visualized as the Gd tracer was cleared from the intersti-tial compartnent rapidly.In contrast,the Gd tracer accumulated at the prior surgical site in the lymphed-ematous limb slowly.Quantitative assessment of Gd clearance demonstrated that accumulation of Gd was correlated with the impedance to lymph flow proximal to the site of surgical lymphatic ablation.Conclusion MR lymphangiography is a feasible and reliable method to be applied to quantitative functional imaging of the lymphatic vasculature in experimental models of lymphedema.